arr-1 Beta-arrestin arr-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: arr-1
Official Full Name: Beta-arrestin arr-1
Primary source: WormBase:WBGene00000195
Locus tag: CELE_F53H8.2
See related: AllianceGenome:WB:WBGene00000195
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable G protein-coupled receptor binding activity. Involved in positive regulation of growth rate. Predicted to be located in dendrite and perikaryon. Predicted to be active in cytoplasm. Is expressed in several structures, including intestine; nervous system; pharynx; reproductive system; and tail. Human ortholog(s) of this gene implicated in glioblastoma; myopia; nicotine dependence; opiate dependence (multiple); and retinal disease (multiple). Orthologous to several human genes including ARRB1 (arrestin beta 1) and ARRB2 (arrestin beta 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See arr-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 10

Sequence:: Chromosome: X; NC_003284.9 (950782..954233)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We find that VANG-1 promotes Wnt signaling by facilitating Frizzled endocytosis and genetically acts in a common pathway with arr-1/beta-arrestin, whose mutation results in defective PLM branching and F-actin patterns similar to those in the Wnt, mig-1 or vang-1 mutants. On the other hand, the UNC-6/Netrin pathway intersects orthogonally with Wnt-PCP signaling to guide PLM branch growth along the dorsal-ventral axis.
Title: A Wnt-planar polarity pathway instructs neurite branching by restricting F-actin assembly through endosomal signaling.
ARR-1 functions to regulate chemosensory signaling, enabling organisms to adapt to a variety of environmental cues, and provide an in vivo link between arrestin, receptor endocytosis, and temporal recovery from adaptation
Title: Caenorhabditus elegans arrestin regulates neural G protein signaling and olfactory adaptation and recovery.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F53H8.2 (e-PCR)
- UniSTS:311760

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor internalization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of growth rate	IGI Inferred from Genetic Interaction more info	PubMed
involved_in response to stimulus	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in perikaryon	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Beta-arrestin arr-1

NP_508183.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

950782..954233

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_075782.8 → NP_508183.1 Beta-arrestin arr-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508183.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P51485

Conserved Domains (2) summary

smart01017
Location:205 → 363

Arrestin_C; Arrestin (or S-antigen), C-terminal domain

pfam00339
Location:22 → 186

Arrestin_N; Arrestin (or S-antigen), N-terminal domain