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dgk-1 Diacylglycerol kinase [ Caenorhabditis elegans ]

Gene ID: 180452, updated on 14-Nov-2024

Summary

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Official Symbol
dgk-1
Official Full Name
Diacylglycerol kinase
Primary source
WormBase:WBGene00000958
Locus tag
CELE_C09E10.2
See related
AllianceGenome:WB:WBGene00000958
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables ATP-dependent diacylglycerol kinase activity and small GTPase binding activity. Involved in several processes, including cellular response to dopamine; cholinergic synaptic transmission; and lipid phosphorylation. Located in several cellular components, including axon; cell body; and perinuclear region of cytoplasm. Is expressed in excretory cell; nervous system; and reproductive system. Orthologous to human DGKQ (diacylglycerol kinase theta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dgk-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
17
Sequence:
Chromosome: X; NC_003284.9 (983903..991456, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene AB hydrolase-1 domain-containing protein;Protein abhd-3.2 Neighboring gene G protein-coupled receptor Neighboring gene Uncharacterized protein Neighboring gene ZP domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Domains, amino acid residues, and new isoforms of Caenorhabditis elegans diacylglycerol kinase 1 (DGK-1) important for terminating diacylglycerol signaling in vivo. Jose AM, et al. J Biol Chem, 2005 Jan 28. PMID 15563467, Free PMC Article
  2. Rho is a presynaptic activator of neurotransmitter release at pre-existing synapses in C. elegans. McMullan R, et al. Genes Dev, 2006 Jan 1. PMID 16391233, Free PMC Article
  3. A role for RIC-8 (Synembryn) and GOA-1 (G(o)alpha) in regulating a subset of centrosome movements during early embryogenesis in Caenorhabditis elegans. Miller KG, et al. Genetics, 2000 Dec. PMID 11102364, Free PMC Article
  4. nu444 is a novel allele of pkc-1 in C. elegans. Wang H, et al. MicroPubl Biol, 2017 May 18. PMID 32550344, Free PMC Article
  5. Dysregulation of Neuronal Gαo Signaling by Graphene Oxide in Nematode Caenorhabditis elegans. Liu P, et al. Sci Rep, 2019 Apr 15. PMID 30988375, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Forward genetic screen of Caenorhabditis elegans mutants with impaired sleep reveals a crucial role of neuronal diacylglycerol kinase DGK-1 in regulating sleep.
    Title: Forward genetic screen of Caenorhabditis elegans mutants with impaired sleep reveals a crucial role of neuronal diacylglycerol kinase DGK-1 in regulating sleep.
  2. diacylglycerol kinase 1 (DGK-1) is important for terminating diacylglycerol signaling in vivo
    Title: Domains, amino acid residues, and new isoforms of Caenorhabditis elegans diacylglycerol kinase 1 (DGK-1) important for terminating diacylglycerol signaling in vivo.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent diacylglycerol kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ATP-dependent diacylglycerol kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent diacylglycerol kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled dopamine receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycerolipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of defecation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to food IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in serotonin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic transmission, cholinergic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Diacylglycerol kinase
NP_001367480.1
  • Confirmed by transcript evidence
NP_001367482.1
  • Confirmed by transcript evidence
NP_001367483.1
  • Confirmed by transcript evidence
NP_001367484.1
  • Confirmed by transcript evidence
NP_001379646.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    983903..991456 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392723.1 → NP_001379646.1  Diacylglycerol kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q17860
    Conserved Domains (7) summary
    smart00046
    Location:550 → 675
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd17111
    Location:266 → 353
    RA1_DAGK-theta; Ras-associating (RA) domain 1 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins
    pfam00609
    Location:713 → 869
    DAGK_acc; Diacylglycerol kinase accessory domain
    cd20803
    Location:20 → 74
    C1_DGKtheta_typeV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
    cd20804
    Location:79 → 135
    C1_DGKtheta_typeV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
    cd20854
    Location:150 → 212
    C1_DGKtheta_typeV_rpt3; third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
    cl28922
    Location:359 → 452
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  2. NM_001380901.2 → NP_001367480.1  Diacylglycerol kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JNZ1
    Conserved Domains (7) summary
    smart00046
    Location:548 → 673
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd17111
    Location:264 → 351
    RA1_DAGK-theta; Ras-associating (RA) domain 1 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins
    pfam00609
    Location:711 → 867
    DAGK_acc; Diacylglycerol kinase accessory domain
    cd20803
    Location:20 → 74
    C1_DGKtheta_typeV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
    cd20804
    Location:79 → 135
    C1_DGKtheta_typeV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
    cd20854
    Location:150 → 212
    C1_DGKtheta_typeV_rpt3; third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
    cl28922
    Location:357 → 450
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold

  3. NM_001380900.1 → NP_001367482.1  Diacylglycerol kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q58AU6
    Conserved Domains (6) summary
    smart00046
    Location:392 → 517
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG0724
    Location:224 → 373
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam00609
    Location:555 → 711
    DAGK_acc; Diacylglycerol kinase accessory domain
    cd20803
    Location:20 → 74
    C1_DGKtheta_typeV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
    cd20804
    Location:79 → 135
    C1_DGKtheta_typeV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
    cd20854
    Location:150 → 212
    C1_DGKtheta_typeV_rpt3; third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

  4. NM_001380902.1 → NP_001367483.1  Diacylglycerol kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q58AU5
    Conserved Domains (6) summary
    smart00046
    Location:394 → 519
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    COG0724
    Location:238 → 375
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    pfam00609
    Location:557 → 713
    DAGK_acc; Diacylglycerol kinase accessory domain
    cd20803
    Location:20 → 74
    C1_DGKtheta_typeV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
    cd20804
    Location:79 → 135
    C1_DGKtheta_typeV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
    cd20854
    Location:150 → 212
    C1_DGKtheta_typeV_rpt3; third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins

  5. NM_001380904.1 → NP_001367484.1  Diacylglycerol kinase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q58AU4
    Conserved Domains (7) summary
    smart00046
    Location:517 → 642
    DAGKc; Diacylglycerol kinase catalytic domain (presumed)
    cd17111
    Location:249 → 320
    RA1_DAGK-theta; Ras-associating (RA) domain 1 found in diacylgylcerol kinase theta (DAGK-theta) and similar proteins
    pfam00609
    Location:680 → 836
    DAGK_acc; Diacylglycerol kinase accessory domain
    cd20803
    Location:20 → 74
    C1_DGKtheta_typeV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
    cd20804
    Location:79 → 135
    C1_DGKtheta_typeV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
    cd20854
    Location:150 → 212
    C1_DGKtheta_typeV_rpt3; third protein kinase C conserved region 1 (C1 domain) found in type V diacylglycerol kinase, DAG kinase theta, and similar proteins
    cl28922
    Location:326 → 419
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
Nucleotide Protein
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