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pfn-3 Profilin-3 [ Caenorhabditis elegans ]

Gene ID: 180460, updated on 9-Dec-2024

Summary

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Official Symbol
pfn-3
Official Full Name
Profilin-3
Primary source
WormBase:WBGene00003991
Locus tag
CELE_K03E6.6
See related
AllianceGenome:WB:WBGene00003991
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin monomer binding activity. Involved in muscle thin filament assembly. Located in striated muscle dense body. Is expressed in body wall musculature; intestine; and rectal gland cell. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pfn-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
4
Sequence:
Chromosome: X; NC_003284.9 (1079430..1080649, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Band 7 domain-containing protein;Protein unc-1 Neighboring gene B9 domain-containing protein 1 Neighboring gene LIM/homeobox protein lim-6 Neighboring gene Guanine nucleotide exchange factor rei-2 Neighboring gene tRNA-Arg Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans expresses three functional profilins in a tissue-specific manner. Polet D, et al. Cell Motil Cytoskeleton, 2006 Jan. PMID 16317718, Free PMC Article
  2. Bending amplitude - a new quantitative assay of C. elegans locomotion: identification of phenotypes for mutants in genes encoding muscle focal adhesion components. Nahabedian JF, et al. Methods, 2012 Jan. PMID 22126736, Free PMC Article
  3. Sarcomeric actin organization is synergistically promoted by tropomodulin, ADF/cofilin, AIP1 and profilin in C. elegans. Yamashiro S, et al. J Cell Sci, 2008 Dec 1. PMID 18984629, Free PMC Article
  4. Pluronic gel-based burrowing assay for rapid assessment of neuromuscular health in C. elegans. Lesanpezeshki L, et al. Sci Rep, 2019 Oct 23. PMID 31645584, Free PMC Article
  5. Genome-wide prediction of C. elegans genetic interactions. Zhong W, et al. Science, 2006 Mar 10. PMID 16527984

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin monomer binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in muscle thin filament assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sequestering of actin monomers IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in striated muscle dense body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Profilin-3
NP_508205.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    1079430..1080649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075804.7 → NP_508205.1  Profilin-3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508205.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21193, Q5GHR0
    Conserved Domains (1) summary
    cd00148
    Location:2 → 126
    PROF; Profilin binds actin monomers, membrane polyphosphoinositides such as PI(4,5)P2, and poly-L-proline. Profilin can inhibit actin polymerization into F-actin by binding to monomeric actin (G-actin) and terminal F-actin subunits, but - as a regulator of the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21193.1

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