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acly-1 putative ATP-citrate synthase [ Caenorhabditis elegans ]

Gene ID: 180485, updated on 9-Dec-2024

Summary

Official Symbol
acly-1
Official Full Name
putative ATP-citrate synthase
Primary source
WormBase:WBGene00016995
Locus tag
CELE_D1005.1
See related
AllianceGenome:WB:WBGene00016995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP citrate synthase activity. Predicted to be involved in acetyl-CoA biosynthetic process and fatty acid biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Orthologous to human ACLY (ATP citrate lyase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See acly-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (1479542..1484087)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Signal peptide-containing protein Neighboring gene tRNA Neighboring gene Activin_recp domain-containing protein Neighboring gene C-type lectin domain-containing protein

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP citrate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ATP citrate synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables acyltransferase activity, acyl groups converted into alkyl on transfer IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in acetyl-CoA biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in citrate metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
putative ATP-citrate synthase
NP_508280.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    1479542..1484087
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075879.6NP_508280.1  putative ATP-citrate synthase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508280.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P53585
    Conserved Domains (7) summary
    cd06100
    Location:8561096
    CCL_ACL-C; Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA). ...
    PLN02235
    Location:1431
    PLN02235; ATP citrate (pro-S)-lyase
    PLN02522
    Location:4921097
    PLN02522; ATP citrate (pro-S)-lyase
    pfam00549
    Location:660785
    Ligase_CoA; CoA-ligase
    pfam02629
    Location:496600
    CoA_binding; CoA binding domain
    pfam16114
    Location:258432
    Citrate_bind; ATP citrate lyase citrate-binding
    cl17255
    Location:8208
    ATP-grasp_4; ATP-grasp domain