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dhs-25 Estradiol 17-beta-dehydrogenase 8 [ Caenorhabditis elegans ]

Gene ID: 180486, updated on 4-Jan-2025

Summary

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Official Symbol
dhs-25
Official Full Name
Estradiol 17-beta-dehydrogenase 8
Primary source
WormBase:WBGene00000988
Locus tag
CELE_F09E10.3
See related
AllianceGenome:WB:WBGene00000988
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor and quinone binding activity. Predicted to be involved in fatty acid biosynthetic process. Orthologous to human HSD17B8 (hydroxysteroid 17-beta dehydrogenase 8). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See dhs-25 in Genome Data Viewer
Location:
chromosome: X
Exon count:
5
Sequence:
Chromosome: X; NC_003284.9 (1486532..1489326)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Activin_recp domain-containing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene ncRNA Neighboring gene Globin family profile domain-containing protein Neighboring gene ncRNA Neighboring gene Activin_recp domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans F09E10.3 encodes a putative 3-oxoacyl-thioester reductase of mitochondrial type 2 fatty acid synthase FASII that is functional in yeast. Gurvitz A. J Biomed Biotechnol, 2009. PMID 19746209, Free PMC Article
  2. Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans. Feng D, et al. PLoS One, 2024. PMID 38517909, Free PMC Article
  3. CCAR-1 works together with the U2AF large subunit UAF-1 to regulate alternative splicing. Lugano DI, et al. RNA Biol, 2024 Jan. PMID 38126797, Free PMC Article
  4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  5. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
Inferred from Biological aspect of Ancestor
more info
  
enables quinone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Estradiol 17-beta-dehydrogenase 8
NP_508282.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    1486532..1489326
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075881.7 → NP_508282.2  Estradiol 17-beta-dehydrogenase 8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508282.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19246
    Conserved Domains (2) summary
    cd05333
    Location:8 → 245
    BKR_SDR_c; beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs
    PRK05653
    Location:4 → 248
    fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated
Nucleotide Protein
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