kin-29 Serine/threonine-protein kinase kin-29 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: kin-29
Official Full Name: Serine/threonine-protein kinase kin-29
Primary source: WormBase:WBGene00002210
Locus tag: CELE_F58H12.1
See related: AllianceGenome:WB:WBGene00002210
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables histone deacetylase inhibitor activity and protein serine/threonine kinase activity. Involved in several processes, including dauer entry; positive regulation of growth rate; and transforming growth factor beta receptor signaling pathway. Located in cytoplasm and nucleus. Is expressed in body wall musculature; hypodermis; intestine; nervous system; and non-striated muscle. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See kin-29 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 16

Sequence:: Chromosome: X; NC_003284.9 (2843922..2852438, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIN-29 regulates sleep, metabolic stores, and energy charge.
Title: A salt-induced kinase is required for the metabolic regulation of sleep.
KIN-29 is a new regulator of MEF2/HDAC functions in the nervous system.
Title: KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC.
kin-29 is a new modulator of the Sma/Mab pathway. It functions in neurons and in the hypodermis to regulate body size.
Title: C. elegans serine-threonine kinase KIN-29 modulates TGFbeta signaling and regulates body size formation.
describe specific genetic interaction between tax-6 and kin-29 in regulating body size, serotonin mediated egg laying, and chemoreceptor expression
Title: Calcineurin interacts with KIN-29, a Ser/Thr kinase, in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F58H12.1 (e-PCR)
- UniSTS:305652

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables histone deacetylase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in dauer entry	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of fatty acid biosynthetic process	TAS Traceable Author Statement more info	PubMed
acts_upstream_of positive regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of growth rate	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of growth rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of multicellular organism growth	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of multicellular organism growth	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to heat	IEP Inferred from Expression Pattern more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Serine/threonine-protein kinase kin-29

NP_508493.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

2843922..2852438 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076092.7 → NP_508493.1 Serine/threonine-protein kinase kin-29 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_508493.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21017

Conserved Domains (2) summary

smart00220
Location:16 → 267

S_TKc; Serine/Threonine protein kinases, catalytic domain

cl21453
Location:16 → 267

PKc_like; Protein Kinases, catalytic domain