osm-5 Intraflagellar transport protein 88 homolog [Caenorhabditis elegans] - Gene

Summary

Official Symbol: osm-5
Official Full Name: Intraflagellar transport protein 88 homolog
Primary source: WormBase:WBGene00003885
Locus tag: CELE_Y41G9A.1
See related: AllianceGenome:WB:WBGene00003885
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable kinesin binding activity. Involved in several processes, including dauer entry; locomotory exploration behavior; and non-motile cilium assembly. Located in ciliary basal body; neuron projection; and non-motile cilium. Part of intraciliary transport particle B. Is expressed in amphid sensillum and neurons. Used to study autosomal dominant polycystic kidney disease. Orthologous to human IFT88 (intraflagellar transport 88). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables kinesin binding	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in cilium assembly	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dauer entry	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intraciliary transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in locomotory exploration behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in non-motile cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in non-motile cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
is_active_in ciliary basal body	IBA Inferred from Biological aspect of Ancestor more info
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
is_active_in ciliary base	IBA Inferred from Biological aspect of Ancestor more info
part_of intraciliary transport particle B	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	IDA Inferred from Direct Assay more info	PubMed
is_active_in non-motile cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed

NP_508511.1

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