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tmem-24 C2 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180654, updated on 4-Jan-2025

Summary

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Official Symbol
tmem-24
Official Full Name
C2 domain-containing protein
Primary source
WormBase:WBGene00020012
Locus tag
CELE_R11G1.6
See related
AllianceGenome:WB:WBGene00020012
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metal ion binding activity. Located in plasma membrane. Orthologous to human C2CD2 (C2 calcium dependent domain containing 2) and C2CD2L (C2CD2 like). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See tmem-24 in Genome Data Viewer
Location:
chromosome: X
Exon count:
15
Sequence:
Chromosome: X; NC_003284.9 (3639166..3644896, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Putative sulfotransferase vep-2 Neighboring gene Glutathione S-Transferase Neighboring gene Serine/threonine-protein kinase sax-1 Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PDZD-8 and TEX-2 regulate endosomal PI(4,5)P(2) homeostasis via lipid transport to promote embryogenesis in C. elegans. Jeyasimman D, et al. Nat Commun, 2021 Oct 18. PMID 34663803, Free PMC Article
  2. The TORC1 phosphoproteome in C. elegans reveals roles in transcription and autophagy. Sewell AK, et al. iScience, 2022 May 20. PMID 35479415, Free PMC Article
  3. Determining the sub-cellular localization of proteins within Caenorhabditis elegans body wall muscle. Meissner B, et al. PLoS One, 2011. PMID 21611156, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
C2 domain-containing protein
NP_001024860.1
  • Confirmed by transcript evidence
NP_001379604.1
  • Confirmed by transcript evidence
NP_741752.1
  • Confirmed by transcript evidence
NP_741753.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    3639166..3644896 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171654.6 → NP_741752.1  C2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741752.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MPZ6
    Conserved Domains (2) summary
    cd08678
    Location:408 → 532
    C2_C21orf25-like; C2 domain found in the Human chromosome 21 open reading frame 25 (C21orf25) protein
    smart00109
    Location:815 → 865
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

  2. NM_171946.7 → NP_741753.1  C2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741753.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYE1
    Conserved Domains (2) summary
    cd08678
    Location:408 → 532
    C2_C21orf25-like; C2 domain found in the Human chromosome 21 open reading frame 25 (C21orf25) protein
    smart00109
    Location:815 → 867
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

  3. NM_001029689.7 → NP_001024860.1  C2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024860.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7Z1P8
    Conserved Domains (2) summary
    cd08678
    Location:318 → 442
    C2_C21orf25-like; C2 domain found in the Human chromosome 21 open reading frame 25 (C21orf25) protein
    smart00109
    Location:725 → 775
    C1; Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains)

  4. NM_001392748.1 → NP_001379604.1  C2 domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7Z1P9
    Conserved Domains (3) summary
    cd08678
    Location:318 → 442
    C2_C21orf25-like; C2 domain found in the Human chromosome 21 open reading frame 25 (C21orf25) protein
    pfam18696
    Location:77 → 222
    SMP_C2CD2L; Synaptotagmin-like, mitochondrial and lipid-binding domain
    cd20831
    Location:720 → 779
    C1_dGM13116p-like; protein kinase C conserved region 1 (C1 domain) found in Drosophila melanogaster GM13116p and similar proteins
Nucleotide Protein
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