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lst-2 Lateral signaling target protein 2 [ Caenorhabditis elegans ]

Gene ID: 180712, updated on 4-Jan-2025

Summary

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Official Symbol
lst-2
Official Full Name
Lateral signaling target protein 2
Primary source
WormBase:WBGene00003084
Locus tag
CELE_R160.7
See related
AllianceGenome:WB:WBGene00003084
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylinositol-3-phosphate binding activity. Predicted to be involved in negative regulation of epidermal growth factor receptor signaling pathway. Predicted to be active in early endosome membrane. Orthologous to human ZFYVE28 (zinc finger FYVE-type containing 28). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See lst-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (4378004..4383366, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene DUF4492 domain-containing protein Neighboring gene Methyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AP-2 complex subunit mu

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Monoubiquitinylation regulates endosomal localization of Lst2, a negative regulator of EGF receptor signaling. Mosesson Y, et al. Dev Cell, 2009 May. PMID 19460345, Free PMC Article
  2. Executing multicellular differentiation: quantitative predictive modelling of C.elegans vulval development. Bonzanni N, et al. Bioinformatics, 2009 Aug 15. PMID 19515963
  3. The WD40 and FYVE domain containing protein 2 defines a class of early endosomes necessary for endocytosis. Hayakawa A, et al. Proc Natl Acad Sci U S A, 2006 Aug 8. PMID 16873553, Free PMC Article
  4. Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development. Yoo AS, et al. Science, 2004 Jan 30. PMID 14752159
  5. RTK/Ras/MAPK signaling. Sundaram MV. WormBook, 2006 Feb 11. PMID 18050474, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol-3-phosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of epidermal growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in early endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Lateral signaling target protein 2
NP_508756.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4378004..4383366 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076355.6 → NP_508756.2  Lateral signaling target protein 2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508756.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9TZD0
    Conserved Domains (2) summary
    cd15731
    Location:559 → 623
    FYVE_LST2; FYVE domain found in lateral signaling target protein 2 homolog (Lst2) and similar proteins
    pfam05285
    Location:361 → 453
    SDA1; SDA1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9TZD0.2

Gene LinkOut

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