dpy-23 AP-2 complex subunit mu [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: dpy-23
Official Full Name: AP-2 complex subunit mu
Primary source: WormBase:WBGene00001082
Locus tag: CELE_R160.1
See related: AllianceGenome:WB:WBGene00001082
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable clathrin adaptor activity. Involved in several processes, including necroptotic process; positive regulation of Wnt protein secretion; and protein localization to non-motile cilium. Located in periciliary membrane compartment and synaptic vesicle. Is expressed in anal depressor muscle; germ line; neurons; rectal epithelial cell; and spermatheca. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human AP2M1 (adaptor related protein complex 2 subunit mu 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See dpy-23 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 11

Sequence:: Chromosome: X; NC_003284.9 (4389359..4393803)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

AP2M1 Supports TGF-beta Signals to Promote Collagen Expression by Inhibiting Caveolin Expression.
Title: AP2M1 Supports TGF-β Signals to Promote Collagen Expression by Inhibiting Caveolin Expression.
We show that compromised sensory signaling alters cilia membrane phosphoinositide composition via TUB-1-dependent trafficking of a PIP5 kinase. TUB-1 regulates localization of this lipid kinase at the cilia base in part via localization of the AP-2 adaptor complex subunit DPY-23.
Title: The Caenorhabditis elegans Tubby homolog dynamically modulates olfactory cilia membrane morphogenesis and phospholipid composition.
AP2 complex can function as two semi-independent hemicomplexes contributing to synaptic vesicle endocytosis.
Title: AP2 hemicomplexes contribute independently to synaptic vesicle endocytosis.
Levels of GluR GLR-1 decreased at synapses in ventral nerve cord (VNC) of Caenorhabditis elegans with mutations in AP2 subunits APM-2/mu2, APA-2/alpha or APS-2/sigma2. Genetic analyses suggest that APM-2/mu2 acts upstream of GLR-1 endocytosis in VNC.
Title: The AP2 clathrin adaptor protein complex regulates the abundance of GLR-1 glutamate receptors in the ventral nerve cord of Caenorhabditis elegans.
Mu2 adaptin/dpy-23 facilitates but is not essential for synaptic vesicle recycling in Caenorhabditis elegans.
Title: Mu2 adaptin facilitates but is not essential for synaptic vesicle recycling in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R160.1 (e-PCR)
- UniSTS:319588

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables clathrin adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables molecular_function	ND No biological Data available more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in clathrin-dependent endocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in clathrin-dependent endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in necroptotic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of Wnt protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to non-motile cilium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of AP-2 adaptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of clathrin adaptor complex	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated pit	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasmic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in periciliary membrane compartment	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: AP-2 complex subunit mu

NP_001024865.1

Confirmed by transcript evidence

NP_741770.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

4389359..4393803

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171670.7 → NP_741770.1 AP-2 complex subunit mu [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741770.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P35603, Q8MXF2, Q9TZC9

Conserved Domains (2) summary

cl02092
Location:1 → 126

Clat_adaptor_s; Clathrin adaptor complex small chain

cd09251
Location:172 → 440

AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2
NM_001029694.7 → NP_001024865.1 AP-2 complex subunit mu [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024865.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P35603

Conserved Domains (2) summary

cl02092
Location:1 → 126

Clat_adaptor_s; Clathrin adaptor complex small chain

cd09251
Location:166 → 434

AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2