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nhr-45 Nuclear Hormone Receptor family [ Caenorhabditis elegans ]

Gene ID: 180738, updated on 9-Dec-2024

Summary

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Official Symbol
nhr-45
Official Full Name
Nuclear Hormone Receptor family
Primary source
WormBase:WBGene00003635
Locus tag
CELE_F16H11.5
See related
AllianceGenome:WB:WBGene00003635
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See nhr-45 in Genome Data Viewer
Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (4656433..4660318, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Homeobox protein ceh-1 Neighboring gene Major facilitator superfamily domain-containing protein 12 Neighboring gene Transmembrane protein 135 homolog Neighboring gene SPLDEEDFAPESPLQ-amide

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nuclear hormone receptors promote gut and glia detoxifying enzyme induction and protect C. elegans from the mold P. brevicompactum. Wallace SW, et al. Cell Rep, 2021 Dec 28. PMID 34965433, Free PMC Article
  2. Mitochondrial Dysfunction in C. elegans Activates Mitochondrial Relocalization and Nuclear Hormone Receptor-Dependent Detoxification Genes. Mao K, et al. Cell Metab, 2019 May 7. PMID 30799287, Free PMC Article
  3. Global analysis of dauer gene expression in Caenorhabditis elegans. Wang J, et al. Development, 2003 Apr. PMID 12620986
  4. Functional modularity of nuclear hormone receptors in a Caenorhabditis elegans metabolic gene regulatory network. Arda HE, et al. Mol Syst Biol, 2010 May 11. PMID 20461074, Free PMC Article
  5. The Caenorhabditis elegans ARIP-4 DNA helicase couples mitochondrial surveillance to immune, detoxification, and antiviral pathways. Mao K, et al. Proc Natl Acad Sci U S A, 2022 Dec 6. PMID 36445965, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear Hormone Receptor family
NP_508797.3
  • Product from WormBase gene class nhr;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4656433..4660318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076396.8 → NP_508797.3  Nuclear Hormone Receptor family [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508797.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19496
    Conserved Domains (2) summary
    cd06157
    Location:305 → 494
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    smart00399
    Location:3 → 71
    ZnF_C4; c4 zinc finger in nuclear hormone receptors
Nucleotide Protein
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