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mig-13 Abnormal cell migration protein 13 [ Caenorhabditis elegans ]

Gene ID: 180755, updated on 4-Jan-2025

Summary

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Official Symbol
mig-13
Official Full Name
Abnormal cell migration protein 13
Primary source
WormBase:WBGene00003245
Locus tag
CELE_F43C9.4
See related
AllianceGenome:WB:WBGene00003245
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in positive regulation of cell migration. Located in axon; neuronal cell body; and plasma membrane. Is expressed in several structures, including QR.a; QR.p; QR.pa; neurons; and pharyngeal-intestinal valve. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See mig-13 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (4796099..4799646, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Calmodulin;EF-hand domain-containing protein Neighboring gene tRNA-Lys Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Toward Universal Forward Genetics: Using a Draft Genome Sequence of the Nematode Oscheius tipulae To Identify Mutations Affecting Vulva Development. Besnard F, et al. Genetics, 2017 Aug. PMID 28630114, Free PMC Article
  2. Spatial confinement of receptor activity by tyrosine phosphatase during directional cell migration. Zhu Z, et al. Proc Natl Acad Sci U S A, 2020 Jun 23. PMID 32513699, Free PMC Article
  3. A novel bipartite UNC-101/AP-1 μ1 binding signal mediates KVS-4/Kv2.1 somatodendritic distribution in Caenorhabditis elegans. Zhou X, et al. FEBS Lett, 2016 Jan. PMID 26762178
  4. Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration. Wang X, et al. Proc Natl Acad Sci U S A, 2013 Jul 2. PMID 23784779, Free PMC Article
  5. MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans. Masuda H, et al. FEBS Lett, 2012 Mar 23. PMID 22293500

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MIG-13, an evolutionarily conserved transmembrane protein, cell-autonomously regulates the asymmetric distribution of the actin cytoskeleton in the leading migratory edge.
    Title: Transmembrane protein MIG-13 links the Wnt signaling and Hox genes to the cell polarity in neuronal migration.
  2. Data suggest that MIG-13 controls anteroposterior cell migration by interacting with UNC-71 and SRC-1 in C. elegans.
    Title: MIG-13 controls anteroposterior cell migration by interacting with UNC-71/ADM-1 and SRC-1 in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in positive regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IEA
Inferred from Electronic Annotation
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Abnormal cell migration protein 13
NP_001024660.1
  • Confirmed by transcript evidence
NP_001024661.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4796099..4799646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029489.7 → NP_001024660.1  Abnormal cell migration protein 13 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024660.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EF33, H2KZ96
    Conserved Domains (2) summary
    smart00192
    Location:183 → 213
    LDLa; Low-density lipoprotein receptor domain class A
    smart00042
    Location:52 → 172
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein

  2. NM_001029490.5 → NP_001024661.1  Abnormal cell migration protein 13 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024661.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EF33
    Conserved Domains (2) summary
    smart00192
    Location:177 → 207
    LDLa; Low-density lipoprotein receptor domain class A
    smart00042
    Location:46 → 166
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EF33.1

Gene LinkOut

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