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ztf-16 Zinc finger protein ztf-16 [ Caenorhabditis elegans ]

Gene ID: 180756, updated on 4-Jan-2025

Summary

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Official Symbol
ztf-16
Official Full Name
Zinc finger protein ztf-16
Primary source
WormBase:WBGene00019960
Locus tag
CELE_R08E3.4
See related
AllianceGenome:WB:WBGene00019960
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in gonad development and positive regulation of gene expression. Located in nucleus. Is expressed in several structures, including accessory cell; gonad; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; acute lymphoblastic leukemia; colorectal cancer; common variable immunodeficiency 13; and primary immunodeficiency disease. Orthologous to several human genes including IKZF1 (IKAROS family zinc finger 1); IKZF2 (IKAROS family zinc finger 2); and IKZF3 (IKAROS family zinc finger 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ztf-16 in Genome Data Viewer
Location:
chromosome: X
Exon count:
11
Sequence:
Chromosome: X; NC_003284.9 (4805998..4811540, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. hunchback and Ikaros-like zinc finger genes control reproductive system development in Caenorhabditis elegans. Large EE, et al. Dev Biol, 2010 Mar 1. PMID 20026024, Free PMC Article
  2. Sensory organ remodeling in Caenorhabditis elegans requires the zinc-finger protein ZTF-16. Procko C, et al. Genetics, 2012 Apr. PMID 22298710, Free PMC Article
  3. TRPM channels are required for rhythmicity in the ultradian defecation rhythm of C. elegans. Kwan CS, et al. BMC Physiol, 2008 May 21. PMID 18495023, Free PMC Article
  4. mRNA profiling reveals significant transcriptional differences between a multipotent progenitor and its differentiated sister. Mathies LD, et al. BMC Genomics, 2019 May 28. PMID 31138122, Free PMC Article
  5. Microtubule severing by the katanin complex is activated by PPFR-1-dependent MEI-1 dephosphorylation. Gomes JE, et al. J Cell Biol, 2013 Aug 5. PMID 23918937, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ztf-16 functions within glia to regulate ver-1 expression.
    Title: Sensory organ remodeling in Caenorhabditis elegans requires the zinc-finger protein ZTF-16.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in gonad development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Zinc finger protein ztf-16
NP_001024850.1
  • Confirmed by transcript evidence
NP_001024851.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    4805998..4811540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029680.6 → NP_001024851.1  Zinc finger protein ztf-16 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024851.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2L008, Q5WRS1
    Conserved Domains (1) summary
    sd00017
    Location:105 → 125
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001029679.5 → NP_001024850.1  Zinc finger protein ztf-16 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024850.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5WRS1
    Conserved Domains (1) summary
    sd00017
    Location:105 → 125
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
H2L008.1

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