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ags-3 Activator of G protein signaling;TPR_REGION domain-containing protein;Tetratricopeptide repeat protein 28 [ Caenorhabditis elegans ]

Gene ID: 180801, updated on 4-Jan-2025

Summary

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Official Symbol
ags-3
Official Full Name
Activator of G protein signaling;TPR_REGION domain-containing protein;Tetratricopeptide repeat protein 28
Primary source
WormBase:WBGene00000092
Locus tag
CELE_F32A6.4
See related
AllianceGenome:WB:WBGene00000092
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables G-protein alpha-subunit binding activity. Involved in regulation of feeding behavior. Located in membrane. Is expressed in several structures, including hermaphrodite gonad; intestine; muscle cell; nervous system; and pharynx. Human ortholog(s) of this gene implicated in sensorineural hearing loss. Orthologous to human GPSM1 (G protein signaling modulator 1) and GPSM2 (G protein signaling modulator 2). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ags-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
16
Sequence:
Chromosome: X; NC_003284.9 (5289728..5303600, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Rho-GAP domain-containing protein Neighboring gene UV radiation resistance-associated gene protein-like Neighboring gene tRNA Neighboring gene Vacuolar protein sorting-associated protein 41 homolog Neighboring gene ncRNA Neighboring gene IFT81 calponin homology domain-containing protein Neighboring gene ncRNA Neighboring gene Stomatin-2 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The G protein regulator AGS-3 allows C. elegans to alter behaviors in response to food deprivation. Hofler C, et al. Worm, 2012 Jan 1. PMID 24058824, Free PMC Article
  2. The G protein alpha chaperone and guanine-nucleotide exchange factor RIC-8 regulates cilia morphogenesis in Caenorhabditis elegans sensory neurons. Campagna CM, et al. PLoS Genet, 2023 Nov. PMID 37910589, Free PMC Article
  3. AGS-3 alters Caenorhabditis elegans behavior after food deprivation via RIC-8 activation of the neural G protein G αo. Hofler C, et al. J Neurosci, 2011 Aug 10. PMID 21832186, Free PMC Article
  4. Asymmetrically distributed C. elegans homologs of AGS3/PINS control spindle position in the early embryo. Gotta M, et al. Curr Biol, 2003 Jun 17. PMID 12814548
  5. aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division. Galli M, et al. Nat Cell Biol, 2011 Aug 21. PMID 21857670

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A biological role for AGS-3 is identified in response to food deprivation that indicates the mechanism for activation of Galpha(o) signaling in vivo.
    Title: AGS-3 alters Caenorhabditis elegans behavior after food deprivation via RIC-8 activation of the neural G protein G αo.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables G-protein alpha-subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein alpha-subunit binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables GDP-dissociation inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GDP-dissociation inhibitor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables GTPase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in establishment of mitotic spindle orientation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of feeding behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cell cortex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Activator of G protein signaling;TPR_REGION domain-containing protein;Tetratricopeptide repeat protein 28
NP_001309689.1
  • Confirmed by transcript evidence
NP_001309690.1
  • Confirmed by transcript evidence
NP_001309692.1
  • Product from WormBase gene class ags;
    Confirmed by transcript evidence
NP_001370955.1
  • Product from WormBase gene class ags;
    Confirmed by transcript evidence
NP_741787.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    5289728..5303600 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171684.6 → NP_741787.1  Tetratricopeptide repeat protein 28 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741787.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19955
    Conserved Domains (5) summary
    smart00390
    Location:511 → 533
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    sd00006
    Location:186 → 213
    TPR; TPR repeat [structural motif]
    pfam02188
    Location:417 → 437
    GoLoco; GoLoco motif
    pfam13414
    Location:7 → 65
    TPR_11; TPR repeat
    pfam13424
    Location:182 → 255
    TPR_12; Tetratricopeptide repeat

  2. NM_001383577.1 → NP_001370955.1  Activator of G protein signaling [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBC1
    Conserved Domains (1) summary
    smart00390
    Location:90 → 112
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

  3. NM_001322618.4 → NP_001309689.1  TPR_REGION domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MD77
    Conserved Domains (4) summary
    smart00390
    Location:288 → 310
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    sd00006
    Location:3 → 30
    TPR; TPR repeat [structural motif]
    pfam02188
    Location:194 → 214
    GoLoco; GoLoco motif
    pfam13424
    Location:3 → 74
    TPR_12; Tetratricopeptide repeat

  4. NM_001322619.4 → NP_001309690.1  TPR_REGION domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBW5, Q86RT4
    Conserved Domains (2) summary
    smart00390
    Location:245 → 267
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02188
    Location:151 → 171
    GoLoco; GoLoco motif

  5. NM_001322621.4 → NP_001309692.1  Activator of G protein signaling [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MBA1
    Conserved Domains (1) summary
    smart00390
    Location:33 → 55
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases

RNA

  1. NR_136376.1 RNA Sequence

    Status: REVIEWED

  2. NR_136377.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
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