jkk-1 Dual specificity mitogen-activated protein kinase kinase jkk-1 [Caenorhabditis elegans] - Gene

Summary

Official Symbol: jkk-1
Official Full Name: Dual specificity mitogen-activated protein kinase kinase jkk-1
Primary source: WormBase:WBGene00002177
Locus tag: CELE_F35C8.3
See related: AllianceGenome:WB:WBGene00002177
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables JUN kinase kinase activity. Involved in hyperosmotic response and locomotion. Located in axon; cytoplasm; and neuronal cell body. Is expressed in neurons. Human ortholog(s) of this gene implicated in colon adenocarcinoma; lung adenocarcinoma; lung carcinoma; and lung non-small cell carcinoma. Orthologous to human MAP2K7 (mitogen-activated protein kinase kinase 7). [provided by Alliance of Genome Resources, Jan 2025]
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Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables JUN kinase kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables MAP kinase kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables MAP kinase kinase activity	IEA Inferred from Electronic Annotation more info
enables exonuclease activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein tyrosine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in hyperosmotic response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in stress-activated MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info

Preferred Names: Dual specificity mitogen-activated protein kinase kinase jkk-1

NP_001370369.1

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