atat-2 Alpha-tubulin N-acetyltransferase 2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: atat-2
Official Full Name: Alpha-tubulin N-acetyltransferase 2
Primary source: WormBase:WBGene00021059
Locus tag: CELE_W06B11.1
See related: AllianceGenome:WB:WBGene00021059
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables tubulin N-acetyltransferase activity. Involved in thigmotaxis. Predicted to be located in microtubule. Is expressed in ciliated neurons and touch receptor neurons. Orthologous to human ATAT1 (alpha tubulin acetyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See atat-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 6

Sequence:: Chromosome: X; NC_003284.9 (5849100..5851971)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

study reveals an important role for tubulin acetyltransferase activity in presynaptic maintenance, which occurs via the RPM-1/ATAT-2 pathway
Title: Synapse maintenance is impacted by ATAT-2 tubulin acetyltransferase activity and the RPM-1 signaling hub.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

W06B11.1 (e-PCR)
- UniSTS:320375

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables tubulin N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables tubulin N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables tubulin N-acetyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in alpha-tubulin acetylation	IEA Inferred from Electronic Annotation more info
involved_in microtubule cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron development	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in thigmotaxis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thigmotaxis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
located_in microtubule	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Alpha-tubulin N-acetyltransferase 2

NP_001379875.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

5849100..5851971

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001392779.1 → NP_001379875.1 Alpha-tubulin N-acetyltransferase 2 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q23192

Conserved Domains (1) summary

pfam05301
Location:8 → 181

Acetyltransf_16; GNAT acetyltransferase, Mec-17