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ipp-5 inositol-polyphosphate 5-phosphatase;putative type I inositol 1,4,5-trisphosphate 5-phosphatase [ Caenorhabditis elegans ]

Gene ID: 180871, updated on 4-Jan-2025

Summary

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Official Symbol
ipp-5
Official Full Name
inositol-polyphosphate 5-phosphatase;putative type I inositol 1,4,5-trisphosphate 5-phosphatase
Primary source
WormBase:WBGene00002146
Locus tag
CELE_C09B8.1
See related
AllianceGenome:WB:WBGene00002146
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable inositol-polyphosphate 5-phosphatase activity. Involved in negative regulation of epidermal growth factor receptor signaling pathway and ovulation. Is expressed in spermatheca. Orthologous to human INPP5A (inositol polyphosphate-5-phosphatase A). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See ipp-5 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (6031469..6034515)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Transmembrane protein 53 Neighboring gene F-box C protein Neighboring gene SHSP domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Inositol polyphosphate multikinase IPMK-1 regulates development through IP3/calcium signaling in Caenorhabditis elegans. Yang ZL, et al. Cell Calcium, 2021 Jan. PMID 33316585
  2. The Flightless I homolog, fli-1, regulates anterior/posterior polarity, asymmetric cell division and ovulation during Caenorhabditis elegans development. Deng H, et al. Genetics, 2007 Oct. PMID 17720906, Free PMC Article
  3. The DSL ligand APX-1 is required for normal ovulation in C. elegans. McGovern M, et al. Dev Biol, 2018 Mar 15. PMID 29371032, Free PMC Article
  4. HLH-29 regulates ovulation in C. elegans by targeting genes in the inositol triphosphate signaling pathway. White A, et al. Biol Open, 2012 Mar 15. PMID 23213416, Free PMC Article
  5. Regulation of maternal phospholipid composition and IP(3)-dependent embryonic membrane dynamics by a specific fatty acid metabolic event in C. elegans. Kniazeva M, et al. Genes Dev, 2012 Mar 15. PMID 22426533, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol phosphate phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol-1,4,5-trisphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol-polyphosphate 5-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables inositol-polyphosphate 5-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of epidermal growth factor receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ovulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol dephosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
inositol-polyphosphate 5-phosphatase;putative type I inositol 1,4,5-trisphosphate 5-phosphatase
NP_001348790.1
  • Confirmed by transcript evidence
NP_509008.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    6031469..6034515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001361812.4 → NP_001348790.1  inositol-polyphosphate 5-phosphatase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A2K5AU07
    Conserved Domains (1) summary
    cl00490
    Location:2 → 408
    EEP; Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily

  2. NM_076607.9 → NP_509008.2  putative type I inositol 1,4,5-trisphosphate 5-phosphatase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509008.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17848, Q8WRS7
    Conserved Domains (1) summary
    cd09092
    Location:2 → 409
    INPP5A; Type I inositol polyphosphate 5-phosphatase I
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17848.2

Gene LinkOut

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