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nhx-4 Sodium/hydrogen exchanger [ Caenorhabditis elegans ]

Gene ID: 180964, updated on 4-Jan-2025

Summary

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Official Symbol
nhx-4
Official Full Name
Sodium/hydrogen exchanger
Primary source
WormBase:WBGene00003732
Locus tag
CELE_F14B8.1
See related
AllianceGenome:WB:WBGene00003732
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable potassium:proton antiporter activity and sodium:proton antiporter activity. Predicted to be involved in potassium ion transmembrane transport; regulation of intracellular pH; and sodium ion import across plasma membrane. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed widely. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See nhx-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
13
Sequence:
Chromosome: X; NC_003284.9 (6914289..6921136)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Systemic RNA interference defective protein 5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Otopetrin-2 Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein;Protein kinase domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The NHX family of Na+-H+ exchangers in Caenorhabditis elegans. Nehrke K, et al. J Biol Chem, 2002 Aug 9. PMID 12021279
  2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:proton antiporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sodium:proton antiporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in monoatomic cation transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of intracellular pH IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of pH IEA
Inferred from Electronic Annotation
more info
  
involved_in sodium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Sodium/hydrogen exchanger
NP_001024562.1
  • Confirmed by transcript evidence
NP_001367515.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    6914289..6921136
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029391.5 → NP_001024562.1  Sodium/hydrogen exchanger [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024562.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDU2
    Conserved Domains (2) summary
    TIGR00840
    Location:94 → 637
    b_cpa1; sodium/hydrogen exchanger 3
    pfam00999
    Location:104 → 508
    Na_H_Exchanger; Sodium/hydrogen exchanger family

  2. NM_001381015.2 → NP_001367515.1  Sodium/hydrogen exchanger [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECB7
    Conserved Domains (1) summary
    TIGR00840
    Location:29 → 572
    b_cpa1; sodium/hydrogen exchanger 3
Nucleotide Protein
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