lam-2 Laminin-like protein lam-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: lam-2
Official Full Name: Laminin-like protein lam-2
Primary source: WormBase:WBGene00016913
Locus tag: CELE_C54D1.5
See related: AllianceGenome:WB:WBGene00016913
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in positive regulation of locomotion. Predicted to be active in basement membrane. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa and lung small cell carcinoma. Orthologous to several human genes including LAMC1 (laminin subunit gamma 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See lam-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 12

Sequence:: Chromosome: X; NC_003284.9 (7143846..7151239, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C54D1.5 (e-PCR)
- UniSTS:309411

STS6-30 (e-PCR)
- UniSTS:242638

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of locomotion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in tissue development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in basement membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Laminin-like protein lam-2

NP_509204.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

7143846..7151239 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076803.7 → NP_509204.3 Laminin-like protein lam-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509204.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q18823

Conserved Domains (8) summary

smart00136
Location:45 → 285

LamNT; Laminin N-terminal domain (domain VI)

smart00180
Location:946 → 991

EGF_Lam; Laminin-type epidermal growth factor-like domai

smart00281
Location:560 → 684

LamB; Laminin B domain

smart00283
Location:1048 → 1262

MA; Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer)

cd00055
Location:993 → 1041

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

pfam00053
Location:835 → 890

Laminin_EGF; Laminin EGF domain

cl00693
Location:1109 → 1165

CM_2; Chorismate mutase type II

cl23763
Location:1179 → 1358

MCP_signal; Methyl-accepting chemotaxis protein (MCP), signaling domain