sur-5 Acetoacetyl-CoA synthetase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sur-5
Official Full Name: Acetoacetyl-CoA synthetase
Primary source: WormBase:WBGene00006351
Locus tag: CELE_K03A1.5
See related: AllianceGenome:WB:WBGene00006351
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable acetoacetate-CoA ligase activity. Predicted to be involved in fatty acid metabolic process. Predicted to be located in cytoplasm and nucleus. Is expressed in several structures, including P3.p hermaphrodite; P4.p hermaphrodite; gonad; hypodermal cell; and somatic cell. Orthologous to human AACS (acetoacetyl-CoA synthetase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See sur-5 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 12

Sequence:: Chromosome: X; NC_003284.9 (7301389..7305570, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K03A1.5 (e-PCR)
- UniSTS:311386

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acetoacetate-CoA ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetoacetate-CoA ligase activity	IEA Inferred from Electronic Annotation more info
enables ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Acetoacetyl-CoA synthetase

NP_509229.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

7301389..7305570 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076828.9 → NP_509229.1 Acetoacetyl-CoA synthetase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509229.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21166

Conserved Domains (2) summary

cd05943
Location:69 → 695

AACS; Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS)

PRK03584
Location:62 → 699

PRK03584; acetoacetyl-CoA synthetase; Provisional