spp-3 Saposin B-type domain-containing protein [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: spp-3
Official Full Name: Saposin B-type domain-containing protein
Primary source: WormBase:WBGene00004988
Locus tag: CELE_T08A9.7
See related: AllianceGenome:WB:WBGene00004988
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables identical protein binding activity. Involved in defense response to Gram-negative bacterium and defense response to Gram-positive bacterium. Part of protein-containing complex. Is expressed in SDQR and intestine. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See spp-3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 2

Sequence:: Chromosome: X; NC_003284.9 (7314969..7315353, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SPP-3 is a protein with antimicrobial activity that is presumably part of the redundant armamentarium of effector proteins in the worm's intestine, may help to protect neurons, and appears to be involved in regulating reproduction.
Title: SPP-3, a saposin-like protein of Caenorhabditis elegans, displays antimicrobial and pore-forming activity and is located in the intestine and in one head neuron.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T08A9.7 (e-PCR)
- UniSTS:319626

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to Gram-negative bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to Gram-positive bacterium	IDA Inferred from Direct Assay more info	PubMed
involved_in innate immune response	HEP more info	PubMed

Component	Evidence Code	Pubs
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Saposin B-type domain-containing protein

NP_509235.2

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

7314969..7315353 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_076834.8 → NP_509235.2 Saposin B-type domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509235.2

Status: REVIEWED

UniProtKB/TrEMBL

Q22336

Conserved Domains (1) summary

smart00741
Location:24 → 100

SapB; Saposin (B) Domains