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deg-1 Degenerin deg-1 [ Caenorhabditis elegans ]

Gene ID: 181035, updated on 9-Dec-2024

Summary

Official Symbol
deg-1
Official Full Name
Degenerin deg-1
Primary source
WormBase:WBGene00000950
Locus tag
CELE_C47C12.6
See related
AllianceGenome:WB:WBGene00000950
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ligand-gated sodium channel activity. Involved in response to acidic pH and response to amino acid. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in AVG; IL1 neuron; anal depressor muscle; body wall musculature; and command interneuron. Used to study hypokalemic periodic paralysis and neurodegenerative disease. Human ortholog(s) of this gene implicated in Liddle syndrome; bronchiectasis 1; bronchiectasis 3; and pseudohypoaldosteronism. Orthologous to human SCNN1B (sodium channel epithelial 1 subunit beta); SCNN1D (sodium channel epithelial 1 subunit delta); and SCNN1G (sodium channel epithelial 1 subunit gamma). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See deg-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
22
Sequence:
Chromosome: X; NC_003284.9 (7753070..7774817)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene RGS domain-containing protein Neighboring gene Zinc finger transcription factor ref-2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene tRNA-Asn Neighboring gene ncRNA Neighboring gene tRNA-Asn Neighboring gene tRNA-Asn Neighboring gene Tubulin beta-1 chain Neighboring gene Uncharacterized protein Neighboring gene Apple domain-containing protein

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ligand-gated sodium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
 
enables sodium channel activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
 
involved_in response to acidic pH IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to amino acid IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in response to amino acid IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sodium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in sodium ion transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
Degenerin deg-1
NP_001360706.1
  • Partially confirmed by transcript evidence
NP_001360707.1
  • Partially confirmed by transcript evidence
NP_001360708.1
  • Partially confirmed by transcript evidence
NP_001360709.1
  • Confirmed by transcript evidence
NP_001360710.1
  • Confirmed by transcript evidence
NP_001360711.1
  • Partially confirmed by transcript evidence
NP_509311.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    7753070..7774817
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373369.2NP_001360711.1  Degenerin deg-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0ILZ4
    Conserved Domains (1) summary
    TIGR00867
    Location:39710
    deg-1; degenerin
  2. NM_076910.5NP_509311.1  Degenerin deg-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509311.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P24585
    Conserved Domains (2) summary
    TIGR00867
    Location:58730
    deg-1; degenerin
    pfam00858
    Location:431730
    ASC; Amiloride-sensitive sodium channel
  3. NM_001373370.2NP_001360706.1  Degenerin deg-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IN98
    Conserved Domains (1) summary
    TIGR00867
    Location:58796
    deg-1; degenerin
  4. NM_001373371.2NP_001360707.1  Degenerin deg-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V6M3V2
    Conserved Domains (1) summary
    TIGR00867
    Location:58740
    deg-1; degenerin
  5. NM_001373372.2NP_001360708.1  Degenerin deg-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IKC5
    Conserved Domains (1) summary
    TIGR00867
    Location:58722
    deg-1; degenerin
  6. NM_001373373.2NP_001360709.1  Degenerin deg-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IJ47
    Conserved Domains (1) summary
    TIGR00867
    Location:58786
    deg-1; degenerin
  7. NM_001373374.2NP_001360710.1  Degenerin deg-1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0ILJ5
    Conserved Domains (1) summary
    TIGR00867
    Location:58712
    deg-1; degenerin