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tnt-3 TropoNin T;Troponin T [ Caenorhabditis elegans ]

Gene ID: 181052, updated on 4-Jan-2025

Summary

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Official Symbol
tnt-3
Official Full Name
TropoNin T;Troponin T
Primary source
WormBase:WBGene00006588
Locus tag
CELE_C14F5.3
See related
AllianceGenome:WB:WBGene00006588
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable tropomyosin binding activity. Predicted to be involved in muscle contraction and sarcomere organization. Predicted to be part of troponin complex. Human ortholog(s) of this gene implicated in intrinsic cardiomyopathy (multiple) and muscle tissue disease (multiple). Orthologous to human TNNT1 (troponin T1, slow skeletal type); TNNT2 (troponin T2, cardiac type); and TNNT3 (troponin T3, fast skeletal type). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See tnt-3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
17
Sequence:
Chromosome: X; NC_003284.9 (7937633..7945099, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Zwei Ig domain protein zig-4 Neighboring gene Zwei Ig domain protein zig-3 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Intoxication vs. infection: a decade of studying Burkholderia pseudomallei virulence in a simple infection model. Day SR, et al. Virulence, 2012 Oct 1. PMID 23211680, Free PMC Article
  2. Resistance to antimicrobial peptides contributes to persistence of Salmonella typhimurium in the C. elegans intestine. Alegado RA, et al. Cell Microbiol, 2008 Jun. PMID 18221392
  3. A Model for Evolutionary Ecology of Disease: The Case for Caenorhabditis Nematodes and Their Natural Parasites. Gibson AK, et al. J Nematol, 2017 Dec. PMID 29353923, Free PMC Article
  4. Integration of male mating and feeding behaviors in Caenorhabditis elegans. Gruninger TR, et al. J Neurosci, 2006 Jan 4. PMID 16399684, Free PMC Article
  5. A conserved p38 MAP kinase pathway in Caenorhabditis elegans innate immunity. Kim DH, et al. Science, 2002 Jul 26. PMID 12142542

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables tropomyosin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of muscle contraction IEA
Inferred from Electronic Annotation
more info
  
involved_in sarcomere organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of troponin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
TropoNin T;Troponin T
NP_001359846.1
  • Confirmed by transcript evidence
NP_001359847.1
  • Confirmed by transcript evidence
NP_001359848.1
  • Confirmed by transcript evidence
NP_001360657.1
  • Confirmed by transcript evidence
NP_001360658.1
  • Confirmed by transcript evidence
NP_001379643.1
  • Product from WormBase gene class tnt;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    7937633..7945099 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373380.2 → NP_001359846.1  Troponin T [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYL7
    Conserved Domains (1) summary
    pfam00992
    Location:180 → 254
    Troponin

  2. NM_001373381.2 → NP_001359848.1  TropoNin T [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    B9WRS6
    Conserved Domains (1) summary
    pfam00992
    Location:1033 → 1107
    Troponin

  3. NM_001373382.2 → NP_001360657.1  TropoNin T [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V6M4Y3
    Conserved Domains (1) summary
    pfam00992
    Location:1033 → 1107
    Troponin

  4. NM_001373379.1 → NP_001360658.1  Troponin T [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0IK50
    Conserved Domains (1) summary
    pfam00992
    Location:180 → 254
    Troponin

  5. NM_001392804.1 → NP_001379643.1  TropoNin T [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYL9

  6. NM_001373383.2 → NP_001359847.1  TropoNin T [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KYL8
    Conserved Domains (1) summary
    pfam00992
    Location:1033 → 1107
    Troponin
Nucleotide Protein
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