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xol-1 XO lethal protein 1 [ Caenorhabditis elegans ]

Gene ID: 181061, updated on 9-Dec-2024

Summary

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Official Symbol
xol-1
Official Full Name
XO lethal protein 1
Primary source
WormBase:WBGene00006962
Locus tag
CELE_C18A11.5
See related
AllianceGenome:WB:WBGene00006962
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in dosage compensation by hypoactivation of X chromosome; mRNA alternative trans-splicing; and male sex determination. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See xol-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (8041313..8044409)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene tRNA-Pro Neighboring gene SH2 domain-containing protein Neighboring gene Disorganized muscle protein 1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. Luz JG, et al. Genes Dev, 2003 Apr 15. PMID 12672694, Free PMC Article
  2. A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans. Tang W, et al. Dev Cell, 2018 Mar 26. PMID 29456136, Free PMC Article
  3. Somatic sexual differentiation in Caenorhabditis elegans. Wolff JR, et al. Curr Top Dev Biol, 2008. PMID 19118662
  4. The chromosomal signal for sex determination in Caenorhabditis elegans. Meneely PM. Bioessays, 1997 Nov. PMID 9394616
  5. miRNA-Based Regulation of Alternative RNA Splicing in Metazoans. Schorr AL, et al. Int J Mol Sci, 2021 Oct 27. PMID 34769047, Free PMC Article

See all (82) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. xol-1, the master sex-switch gene in C. elegans, is a transcriptional target of the terminal sex-determining factor tra-1.
    Title: xol-1, the master sex-switch gene in C. elegans, is a transcriptional target of the terminal sex-determining factor TRA-1.
  2. The XOL-1 protein integrates both X and autosomal signals to determine sexual fate.
    Title: The T-box transcription factor SEA-1 is an autosomal element of the X:A signal that determines C. elegans sex.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
NOT enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in dosage compensation by hypoactivation of X chromosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA alternative trans-splicing IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in male sex determination IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
XO lethal protein 1
NP_001024418.1
  • Confirmed by transcript evidence
NP_001024419.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    8041313..8044409
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029247.3 → NP_001024418.1  XO lethal protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024418.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18064, Q23229, Q23230, Q23231, Q7JP92
    Conserved Domains (2) summary
    pfam09108
    Location:18 → 177
    Xol-1_N; Switch protein XOL-1, N-terminal
    pfam09109
    Location:184 → 372
    Xol-1_GHMP-like; Switch protein XOL-1, GHMP-like

  2. NM_001029248.1 → NP_001024419.1  XO lethal protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024419.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23229
    Conserved Domains (2) summary
    pfam09108
    Location:18 → 177
    Xol-1_N; Switch protein XOL-1, N-terminal
    pfam09109
    Location:184 → 322
    Xol-1_GHMP-like; Switch protein XOL-1, GHMP-like

RNA

  1. NR_132547.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23229.1

Gene LinkOut

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