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K07E3.4 formate--tetrahydrofolate ligase [ Caenorhabditis elegans ]

Gene ID: 181064, updated on 4-Jan-2025

Summary

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Official Symbol
K07E3.4
Official Full Name
formate--tetrahydrofolate ligase
Primary source
WormBase:WBGene00019492
Locus tag
CELE_K07E3.4
See related
AllianceGenome:WB:WBGene00019492
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP binding activity and formate-tetrahydrofolate ligase activity. Predicted to be involved in tetrahydrofolate interconversion. Is expressed in hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including Down syndrome; abdominal aortic aneurysm; cleft lip; developmental cardiac valvular defect; and neural tube defect (multiple). Orthologous to several human genes including MTHFD1 (methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See K07E3.4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (8080868..8084018, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene methenyltetrahydrofolate cyclohydrolase Neighboring gene Protein vem-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Roles for the RNA polymerase III regulator MAFR-1 in regulating sperm quality in Caenorhabditis elegans. Hammerquist AM, et al. Sci Rep, 2020 Nov 9. PMID 33168938, Free PMC Article
  2. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article
  3. Characterization of the intracellular neurexin interactome by in vivo proximity ligation suggests its involvement in presynaptic actin assembly. Schaan Profes M, et al. PLoS Biol, 2024 Jan. PMID 38252619, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables formate-tetrahydrofolate ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
formate--tetrahydrofolate ligase
NP_509360.1
  • Confirmed by transcript evidence
NP_509361.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    8080868..8084018 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076960.6 → NP_509361.1  formate--tetrahydrofolate ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509361.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21284, Q9TY04
    Conserved Domains (1) summary
    PLN02759
    Location:13 → 640
    PLN02759; Formate--tetrahydrofolate ligase

  2. NM_076959.8 → NP_509360.1  formate--tetrahydrofolate ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509360.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21284, Q9TY04
    Conserved Domains (1) summary
    PLN02759
    Location:13 → 640
    PLN02759; Formate--tetrahydrofolate ligase
Nucleotide Protein
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