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endu-2 Endoribonuclease [ Caenorhabditis elegans ]

Gene ID: 181079, updated on 4-Jan-2025

Summary

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Official Symbol
endu-2
Official Full Name
Endoribonuclease
Primary source
WormBase:WBGene00019779
Locus tag
CELE_M60.2
See related
AllianceGenome:WB:WBGene00019779
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA endonuclease activity. Involved in defense response to Gram-negative bacterium and innate immune response. Is expressed in several structures, including germ line; head muscle; intestine; muscle cell; and neurons. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See endu-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
9
Sequence:
Chromosome: X; NC_003284.9 (8242301..8247869)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene ncRNA Neighboring gene MARVEL domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ion transport domain-containing protein Neighboring gene Tetraspanin family protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Protection of germline immortality by the soma via a secreted endoribonuclease. Qi W, et al. Bioessays, 2021 Dec. PMID 34655094
  2. Author Correction: The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans. Qi W, et al. Nat Commun, 2021 May 28. PMID 34050169, Free PMC Article
  3. The secreted endoribonuclease ENDU-2 from the soma protects germline immortality in C. elegans. Qi W, et al. Nat Commun, 2021 Feb 24. PMID 33627668, Free PMC Article
  4. Endoribonuclease ENDU-2 regulates multiple traits including cold tolerance via cell autonomous and nonautonomous controls in Caenorhabditis elegans. Ujisawa T, et al. Proc Natl Acad Sci U S A, 2018 Aug 28. PMID 30104389, Free PMC Article
  5. Regulation of Nucleotide Metabolism and Germline Proliferation in Response to Nucleotide Imbalance and Genotoxic Stresses by EndoU Nuclease. Jia F, et al. Cell Rep, 2020 Feb 11. PMID 32049015, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ENDU-2 regulates cell type-dependent, cell-autonomous, and cell-nonautonomous cold tolerance.
    Title: Endoribonuclease ENDU-2 regulates multiple traits including cold tolerance via cell autonomous and nonautonomous controls in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables RNA nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Endoribonuclease
NP_509391.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    8242301..8247869
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_076990.8 → NP_509391.1  Endoribonuclease [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509391.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GYM9
    Conserved Domains (1) summary
    pfam09412
    Location:307 → 571
    XendoU; Endoribonuclease XendoU
Nucleotide Protein
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