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wrk-1 Ig-like domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181093, updated on 9-Dec-2024

Summary

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Official Symbol
wrk-1
Official Full Name
Ig-like domain-containing protein
Primary source
WormBase:WBGene00006942
Locus tag
CELE_F41D9.3
See related
AllianceGenome:WB:WBGene00006942
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable axon guidance receptor activity. Predicted to be involved in homophilic cell adhesion via plasma membrane adhesion molecules and synapse organization. Predicted to be located in cytoplasm. Predicted to be active in axon; neuronal cell body; and plasma membrane. Is expressed in several structures, including coelomocyte; excretory gland cell; hermaphrodite distal tip cell; interfacial epithelial cell; and neurons. [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See wrk-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
10
Sequence:
Chromosome: X; NC_003284.9 (8387442..8392589, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene tRNA-Arg Neighboring gene tRNA-Arg Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. wrk-1 and rig-5 control pioneer and follower axon navigation in the ventral nerve cord of Caenorhabditis elegans in a nid-1 mutant background. Feresten AH, et al. Genetics, 2023 Mar 2. PMID 36573271, Free PMC Article
  2. Developmental regulation of whole cell capacitance and membrane current in identified interneurons in C. elegans. Faumont S, et al. J Neurophysiol, 2006 Jun. PMID 16554520
  3. A novel Eph receptor-interacting IgSF protein provides C. elegans motoneurons with midline guidepost function. Boulin T, et al. Curr Biol, 2006 Oct 10. PMID 17027485
  4. Genome-wide functional analysis of CREB/long-term memory-dependent transcription reveals distinct basal and memory gene expression programs. Lakhina V, et al. Neuron, 2015 Jan 21. PMID 25611510, Free PMC Article
  5. Cell adhesion receptors in C. elegans. Cox EA, et al. J Cell Sci, 2004 Apr 15. PMID 15090591

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. wrk-1 and rig-5 control pioneer and follower axon navigation in the ventral nerve cord of Caenorhabditis elegans in a nid-1 mutant background.
    Title: wrk-1 and rig-5 control pioneer and follower axon navigation in the ventral nerve cord of Caenorhabditis elegans in a nid-1 mutant background.
  2. WRK-1 acts in eMNs to prevent follower axons from inappropriately crossing the ventral midline.
    Title: A novel Eph receptor-interacting IgSF protein provides C. elegans motoneurons with midline guidepost function.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables axon guidance receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in axon guidance IEA
Inferred from Electronic Annotation
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synapse organization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ig-like domain-containing protein
NP_001024647.1
  • Confirmed by transcript evidence
NP_001024648.1
  • Confirmed by transcript evidence
NP_001024649.1
  • Confirmed by transcript evidence
NP_001024651.1
  • Confirmed by transcript evidence
NP_001360746.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    8387442..8392589 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001029476.4 → NP_001024647.1  Ig-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024647.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZN8, Q8WR44
    Conserved Domains (3) summary
    cd00096
    Location:229 → 302
    Ig; Immunoglobulin domain
    smart00408
    Location:134 → 194
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:25 → 113
    IG_like; Immunoglobulin like

  2. NM_001373391.4 → NP_001360746.1  Ig-like domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4V0ING2, Q8WR43
    Conserved Domains (3) summary
    smart00408
    Location:134 → 196
    IGc2; Immunoglobulin C-2 Type
    smart00409
    Location:25 → 113
    IG; Immunoglobulin
    cl11960
    Location:229 → 313
    Ig; Immunoglobulin domain

  3. NM_001029480.6 → NP_001024651.1  Ig-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024651.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5WRR1, Q8WR43
    Conserved Domains (3) summary
    cd00096
    Location:245 → 318
    Ig; Immunoglobulin domain
    smart00408
    Location:142 → 202
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:25 → 113
    IG_like; Immunoglobulin like

  4. NM_001029477.6 → NP_001024648.1  Ig-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024648.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2KZN9, Q8WR43
    Conserved Domains (3) summary
    cd00096
    Location:237 → 310
    Ig; Immunoglobulin domain
    smart00408
    Location:134 → 194
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:25 → 113
    IG_like; Immunoglobulin like

  5. NM_001029478.5 → NP_001024649.1  Ig-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024649.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MPV0, Q8WR42
    Conserved Domains (2) summary
    smart00408
    Location:134 → 194
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:25 → 113
    IG_like; Immunoglobulin like
Nucleotide Protein
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Gene LinkOut

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