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jbts-14 Transmembrane protein 237 homolog [ Caenorhabditis elegans ]

Gene ID: 181116, updated on 4-Jan-2025

Summary

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Official Symbol
jbts-14
Official Full Name
Transmembrane protein 237 homolog
Primary source
WormBase:WBGene00018727
Locus tag
CELE_F53A9.4
See related
AllianceGenome:WB:WBGene00018727
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in non-motile cilium assembly. Located in ciliary basal body and ciliary transition zone. Is expressed in ciliated neurons. Used to study Joubert syndrome. Human ortholog(s) of this gene implicated in Joubert syndrome and Joubert syndrome 14. Orthologous to human TMEM237 (transmembrane protein 237). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See jbts-14 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (8704306..8707252)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Protein kreg-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Interpreting the pathogenicity of Joubert syndrome missense variants in Caenorhabditis elegans. Lange KI, et al. Dis Model Mech, 2021 Jan 1. PMID 33234550, Free PMC Article
  2. TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone. Huang L, et al. Am J Hum Genet, 2011 Dec 9. PMID 22152675, Free PMC Article
  3. The Ciliary Transition Zone: Finding the Pieces and Assembling the Gate. Gonçalves J, et al. Mol Cells, 2017 Apr. PMID 28401750, Free PMC Article
  4. TMEM107 recruits ciliopathy proteins to subdomains of the ciliary transition zone and causes Joubert syndrome. Lambacher NJ, et al. Nat Cell Biol, 2016 Jan. PMID 26595381, Free PMC Article
  5. A Conserved Role for Girdin in Basal Body Positioning and Ciliogenesis. Nechipurenko IV, et al. Dev Cell, 2016 Sep 12. PMID 27623382, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in cell projection organization IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in non-motile cilium assembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in ciliary transition zone IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary transition zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Transmembrane protein 237 homolog
NP_509471.2
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    8704306..8707252
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077070.7 → NP_509471.2  Transmembrane protein 237 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509471.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20687
    Conserved Domains (1) summary
    pfam15383
    Location:162 → 366
    TMEM237; Transmembrane protein 237
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20687.2

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