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cyn-8 Peptidyl-prolyl cis-trans isomerase 8 [ Caenorhabditis elegans ]

Gene ID: 181136, updated on 4-Jan-2025

Summary

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Official Symbol
cyn-8
Official Full Name
Peptidyl-prolyl cis-trans isomerase 8
Primary source
WormBase:WBGene00000884
Locus tag
CELE_D1009.2
See related
AllianceGenome:WB:WBGene00000884
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables peptidyl-prolyl cis-trans isomerase activity. Predicted to be involved in protein folding. Located in nucleus. Is expressed in intestine and pharynx. Orthologous to human PPIG (peptidylprolyl isomerase G). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See cyn-8 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (8911293..8914261)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Fibrinogen C-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene Neuropeptide-Like Protein Neighboring gene tRNA-Gln Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression pattern and functional significance of a divergent nematode cyclophilin in Caenorhabditis elegans. Page AP, et al. Mol Biochem Parasitol, 1999 Apr 30. PMID 10340496
  2. A novel cyclophilin from parasitic and free-living nematodes with a unique substrate- and drug-binding domain. Ma D, et al. J Biol Chem, 2002 Apr 26. PMID 11847225
  3. Cloning and biochemical characterization of the cyclophilin homologues from the free-living nematode Caenorhabditis elegans. Page AP, et al. Biochem J, 1996 Jul 1. PMID 8694762, Free PMC Article
  4. Identification and comparative analysis of the peptidyl-prolyl cis/trans isomerase repertoires of H. sapiens, D. melanogaster, C. elegans, S. cerevisiae and Sz. pombe. Pemberton TJ, et al. Comp Funct Genomics, 2005. PMID 18629211, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cyclosporin A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidyl-prolyl cis-trans isomerase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptidyl-prolyl cis-trans isomerase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein peptidyl-prolyl isomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Peptidyl-prolyl cis-trans isomerase 8
NP_509507.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    8911293..8914261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077106.2 → NP_509507.1  Peptidyl-prolyl cis-trans isomerase 8 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509507.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P52016, Q95QQ0
    Conserved Domains (2) summary
    cd06503
    Location:324 → 391
    ATP-synt_Fo_b; F-type ATP synthase, membrane subunit b
    cl00197
    Location:10 → 174
    cyclophilin; cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the immunosuppressive drug ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P52016.2

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