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nuc-1 Deoxyribonuclease-2 [ Caenorhabditis elegans ]

Gene ID: 181174, updated on 2-Nov-2024

Summary

Official Symbol
nuc-1
Official Full Name
Deoxyribonuclease-2
Primary source
WormBase:WBGene00003828
Locus tag
CELE_C07B5.5
See related
AllianceGenome:WB:WBGene00003828
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables deoxyribonuclease II activity. Involved in apoptotic DNA fragmentation. Acts upstream of or within with a positive effect on negative regulation of antimicrobial peptide production. Located in lysosome. Is expressed in body wall musculature; head; intestinal cell; and vulva. Orthologous to human DNASE2B (deoxyribonuclease 2 beta) and DNASE2 (deoxyribonuclease 2, lysosomal). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See nuc-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (9539905..9542329)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Nucleolar protein 16;Translation initiation factor IF-2 Neighboring gene tRNA-Val

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables deoxyribonuclease II activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables deoxyribonuclease II activity IEA
Inferred from Electronic Annotation
more info
 
enables deoxyribonuclease II activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in apoptotic DNA fragmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within_positive_effect negative regulation of antimicrobial peptide production IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
Deoxyribonuclease-2
NP_509604.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    9539905..9542329
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077203.9NP_509604.1  Deoxyribonuclease-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509604.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17778
    Conserved Domains (3) summary
    cd09120
    Location:21191
    PLDc_DNaseII_1; Catalytic domain, repeat 1, of Deoxyribonuclease II and similar proteins
    cd09121
    Location:238374
    PLDc_DNaseII_2; Catalytic domain, repeat 2, of Deoxyribonuclease II and similar proteins
    pfam03265
    Location:24371
    DNase_II; Deoxyribonuclease II