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moc-5 GTP 3',8-cyclase [ Caenorhabditis elegans ]

Gene ID: 181176, updated on 9-Dec-2024

Summary

Official Symbol
moc-5
Official Full Name
GTP 3',8-cyclase
Primary source
WormBase:WBGene00009885
Locus tag
CELE_F49E2.1
See related
AllianceGenome:WB:WBGene00009885
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTP 3',8'-cyclase activity and cyclic pyranopterin monophosphate synthase activity. Predicted to be involved in Mo-molybdopterin cofactor biosynthetic process. Predicted to be part of molybdopterin synthase complex. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type A. Orthologous to human MOCS1 (molybdenum cofactor synthesis 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See moc-5 in Genome Data Viewer
Location:
chromosome: X
Exon count:
12
Sequence:
Chromosome: X; NC_003284.9 (9561841..9565981, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Nucleolar protein 16;Translation initiation factor IF-2 Neighboring gene tRNA-Val Neighboring gene SH3 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 4 iron, 4 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables GTP 3',8'-cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables GTP 3',8'-cyclase activity IEA
Inferred from Electronic Annotation
more info
 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables cyclic pyranopterin monophosphate synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cyclic pyranopterin monophosphate synthase activity IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables lyase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in Mo-molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in Mo-molybdopterin cofactor biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of molybdopterin synthase complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
GTP 3',8-cyclase
NP_001343868.1
  • Confirmed by transcript evidence
NP_001380230.1
  • Confirmed by transcript evidence
NP_509611.3
  • Confirmed by transcript evidence
NP_509612.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    9561841..9565981 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077211.7NP_509612.2  GTP 3',8-cyclase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509612.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A0A2C9C399, A0A2C9C3F0, Q20624, Q8T8M9, Q8T8N0
    Conserved Domains (4) summary
    cd01335
    Location:78258
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    cd01420
    Location:454589
    MoaC_PE; MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine ...
    TIGR02666
    Location:67391
    moaA; molybdenum cofactor biosynthesis protein A, bacterial
    pfam06463
    Location:244371
    Mob_synth_C; Molybdenum Cofactor Synthesis C
  2. NM_077210.8NP_509611.3  GTP 3',8-cyclase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509611.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20624
    Conserved Domains (3) summary
    cd01335
    Location:78258
    Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
    TIGR02666
    Location:67389
    moaA; molybdenum cofactor biosynthesis protein A, bacterial
    pfam06463
    Location:244371
    Mob_synth_C; Molybdenum Cofactor Synthesis C
  3. NM_001392824.1NP_001380230.1  GTP 3',8-cyclase [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cl00242
    Location:139
    MoaC; MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor ...
  4. NM_001356794.4NP_001343868.1  GTP 3',8-cyclase [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    PLN02951
    Location:63386
    PLN02951; Molybderin biosynthesis protein CNX2
    cl00242
    Location:442475
    MoaC; MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor ...