pgp-6 P-GlycoProtein related [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pgp-6
Official Full Name: P-GlycoProtein related
Primary source: WormBase:WBGene00004000
Locus tag: CELE_T21E8.1
See related: AllianceGenome:WB:WBGene00004000
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATPase-coupled transmembrane transporter activity and efflux transmembrane transporter activity. Involved in response to nematicide. Predicted to be located in plasma membrane. Predicted to be active in membrane. Is expressed in amphid neurons; head; intestine; and pharynx. Human ortholog(s) of this gene implicated in several diseases, including cholestasis (multiple); drug dependence (multiple); human immunodeficiency virus infectious disease (multiple); inflammatory bowel disease (multiple); and liver disease (multiple). Orthologous to several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pgp-6 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 18

Sequence:: Chromosome: X; NC_003284.9 (10871201..10877425, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T21E8.1 (e-PCR)
- UniSTS:308075

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables efflux transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in response to chemical	IEA Inferred from Electronic Annotation more info
involved_in response to nematicide	IEP Inferred from Expression Pattern more info	PubMed
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: P-GlycoProtein related

NP_001041287.2

Product from WormBase gene class pgp;
Confirmed by transcript evidence

NP_001041288.2

Product from WormBase gene class pgp;
Confirmed by transcript evidence

NP_001257118.1

Product from WormBase gene class pgp;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

10871201..10877425 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001047822.7 → NP_001041287.2 P-GlycoProtein related [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001041287.2

Status: REVIEWED

UniProtKB/TrEMBL

Q22656

Conserved Domains (4) summary

cd03249
Location:381 → 618

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

PTZ00265
Location:32 → 1252

PTZ00265; multidrug resistance protein (mdr1); Provisional

pfam00664
Location:699 → 970

ABC_membrane; ABC transporter transmembrane region

cl00549
Location:47 → 331

ABC_membrane; ABC transporter transmembrane region
NM_001270189.3 → NP_001257118.1 P-GlycoProtein related [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001257118.1

Status: REVIEWED

UniProtKB/TrEMBL

G1K0X0

Conserved Domains (4) summary

cd03249
Location:375 → 612

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

PTZ00265
Location:26 → 1246

PTZ00265; multidrug resistance protein (mdr1); Provisional

pfam00664
Location:693 → 964

ABC_membrane; ABC transporter transmembrane region

cl00549
Location:41 → 325

ABC_membrane; ABC transporter transmembrane region
NM_001047823.5 → NP_001041288.2 P-GlycoProtein related [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001041288.2

Status: REVIEWED

UniProtKB/TrEMBL

Q1ZXU6

Conserved Domains (4) summary

cd03249
Location:322 → 559

ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins

PTZ00265
Location:40 → 1193

PTZ00265; multidrug resistance protein (mdr1); Provisional

pfam00664
Location:640 → 911

ABC_membrane; ABC transporter transmembrane region

cl00549
Location:47 → 272

ABC_membrane; ABC transporter transmembrane region