pxn-2 Peroxidasin homolog pxn-2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pxn-2
Official Full Name: Peroxidasin homolog pxn-2
Primary source: WormBase:WBGene00004257
Locus tag: CELE_K09C8.5
See related: AllianceGenome:WB:WBGene00004257
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable peroxidase activity. Involved in several processes, including embryonic body morphogenesis; muscle attachment; and negative regulation of axon regeneration. Located in basement membrane. Is expressed in PVQL; PVQR; hypodermis; and vulval muscle. Human ortholog(s) of this gene implicated in several diseases, including Alzheimer's disease 1; anterior segment dysgenesis 7; kidney failure (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to several human genes including PXDN (peroxidasin) and PXDNL (peroxidasin like). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See pxn-2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 21

Sequence:: Chromosome: X; NC_003284.9 (10972164..10979286, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

There is a negative relationship between pxn-1 and pxn-2 via pxn-1 regulating pxn-2. Therefore, pxn-1 may function in neuronal development and age-related neuronal maintenance through pxn-2.
Title: pxn-1 and pxn-2 May Interact Negatively during Neuronal Development and Aging in C. elegans.
Peroxidasins are crucial in development and play new role as extracellular inhibitors of axonal regeneration.
Title: The C. elegans peroxidasin PXN-2 is essential for embryonic morphogenesis and inhibits adult axon regeneration.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K09C8.5 (e-PCR)
- UniSTS:307800

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables heme binding	IEA Inferred from Electronic Annotation more info
enables lactoperoxidase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in embryonic body morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in muscle attachment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of axon regeneration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of basement membrane organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basement membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basement membrane	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Peroxidasin homolog pxn-2

NP_509834.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

10972164..10979286 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077433.5 → NP_509834.1 Peroxidasin homolog pxn-2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_509834.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EG78

Conserved Domains (9) summary

PRK15370
Location:35 → 155

PRK15370; type III secretion system effector E3 ubiquitin transferase SlrP

cd09826
Location:798 → 1238

peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins

sd00031
Location:46 → 69

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:28 → 44

LRR_RI; leucine-rich repeat [structural motif]

pfam01462
Location:16 → 43

LRRNT; Leucine rich repeat N-terminal domain

pfam07679
Location:445 → 533

I-set; Immunoglobulin I-set domain

pfam13855
Location:47 → 104

LRR_8; Leucine rich repeat

cd00096
Location:453 → 457

Ig; Ig strand A' [structural motif]

cl11960
Location:346 → 432

Ig; Immunoglobulin domain