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idh-2 Isocitrate dehydrogenase [NADP] [ Caenorhabditis elegans ]

Gene ID: 181311, updated on 2-Nov-2024

Summary

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Official Symbol
idh-2
Official Full Name
Isocitrate dehydrogenase [NADP]
Primary source
WormBase:WBGene00007942
Locus tag
CELE_C34F6.8
See related
AllianceGenome:WB:WBGene00007942
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable isocitrate dehydrogenase (NADP+) activity. Predicted to be involved in NADP metabolic process. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in D-2-hydroxyglutaric aciduria 2; acute myeloid leukemia; carcinoma (multiple); and lung cancer (multiple). Orthologous to human IDH2 (isocitrate dehydrogenase (NADP(+)) 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See idh-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (11216000..11218150)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene NR LBD domain-containing protein Neighboring gene Transmembrane protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene USP domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Fibronectin type-III domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. An anchored experimental design and meta-analysis approach to address batch effects in large-scale metabolomics. Shaver AO, et al. Front Mol Biosci, 2022. PMID 36438654, Free PMC Article
  2. Defective arginine metabolism impairs mitochondrial homeostasis in Caenorhabditiselegans. Tang R, et al. J Genet Genomics, 2020 Mar 20. PMID 32305173
  3. Mitochondrial aconitase suppresses immunity by modulating oxaloacetate and the mitochondrial unfolded protein response. Kim E, et al. Nat Commun, 2023 Jun 22. PMID 37349299, Free PMC Article
  4. Diapause-associated metabolic traits reiterated in long-lived daf-2 mutants in the nematode Caenorhabditis elegans. McElwee JJ, et al. Mech Ageing Dev, 2006 May. PMID 16522328
  5. Germline Maintenance Through the Multifaceted Activities of GLH/Vasa in Caenorhabditis elegans P Granules. Marnik EA, et al. Genetics, 2019 Nov. PMID 31506335, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables isocitrate dehydrogenase (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isocitrate dehydrogenase (NADP+) activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NADP metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glyoxylate cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in isocitrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tricarboxylic acid cycle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Isocitrate dehydrogenase [NADP]
NP_001370015.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11216000..11218150
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383643.2 → NP_001370015.1  Isocitrate dehydrogenase [NADP] [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17643
    Conserved Domains (1) summary
    PTZ00435
    Location:25 → 434
    PTZ00435; isocitrate dehydrogenase; Provisional
Nucleotide Protein
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