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hum-4 Myosin motor domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181335, updated on 9-Dec-2024

Summary

Official Symbol
hum-4
Official Full Name
Myosin motor domain-containing protein
Primary source
WormBase:WBGene00002037
Locus tag
CELE_F46C3.3
See related
AllianceGenome:WB:WBGene00002037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables calmodulin binding activity. Predicted to be involved in actin filament organization and endocytosis. Predicted to be located in cytoskeleton. Predicted to be part of myosin complex. Predicted to be active in several cellular components, including actin cytoskeleton; actin-based cell projection; and cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 3 and sensorineural hearing loss. Orthologous to human MYO15A (myosin XVA) and MYO16 (myosin XVI). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See hum-4 in Genome Data Viewer
Location:
chromosome: X
Exon count:
42
Sequence:
Chromosome: X; NC_003284.9 (11420465..11433588, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables calmodulin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables cytoskeletal motor activity IEA
Inferred from Electronic Annotation
more info
 
enables microfilament motor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in actin-based cell projection IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of myosin complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Myosin motor domain-containing protein
NP_001257158.1
  • Confirmed by transcript evidence
NP_001257159.1
  • Confirmed by transcript evidence
NP_001257161.1
  • Partially confirmed by transcript evidence
NP_001294791.1
  • Confirmed by transcript evidence
NP_001294792.1
  • Confirmed by transcript evidence
NP_001359540.1
  • Confirmed by transcript evidence
NP_001360186.1
  • Confirmed by transcript evidence
NP_001379502.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11420465..11433588 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001373507.3NP_001359540.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20456
    Conserved Domains (7) summary
    smart00015
    Location:680701
    IQ; Calmodulin-binding motif
    smart00139
    Location:21002255
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:22622475
    B41; Band 4.1 homologues
    PRK10263
    Location:11621357
    PRK10263; DNA translocase FtsK; Provisional
    cd14874
    Location:13643
    MYSc_Myo12; class XXXIII myosin, motor domain
    cl17036
    Location:19742030
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:24892563
    PH-like; Pleckstrin homology-like domain
  2. NM_001392845.1NP_001379502.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    C6KRJ0
    Conserved Domains (4) summary
    smart00139
    Location:486641
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:648861
    B41; Band 4.1 homologues
    cl17036
    Location:360416
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:875949
    PH-like; Pleckstrin homology-like domain
  3. NM_001270232.4NP_001257161.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257161.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B6VQ62
    Conserved Domains (5) summary
    smart00139
    Location:523678
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:685898
    B41; Band 4.1 homologues
    pfam00373
    Location:776898
    FERM_M; FERM central domain
    cl17036
    Location:397453
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:912986
    PH-like; Pleckstrin homology-like domain
  4. NM_001373506.3NP_001360186.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6F568
    Conserved Domains (7) summary
    smart00015
    Location:680701
    IQ; Calmodulin-binding motif
    smart00139
    Location:20632218
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:22252438
    B41; Band 4.1 homologues
    PRK10263
    Location:11621357
    PRK10263; DNA translocase FtsK; Provisional
    cd14874
    Location:13643
    MYSc_Myo12; class XXXIII myosin, motor domain
    cl17036
    Location:19371993
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:24522526
    PH-like; Pleckstrin homology-like domain
  5. NM_001307862.4NP_001294791.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294791.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6FD20
    Conserved Domains (7) summary
    smart00139
    Location:8611016
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:10231236
    B41; Band 4.1 homologues
    pfam00373
    Location:11141236
    FERM_M; FERM central domain
    pfam15752
    Location:191
    DUF4688; Domain of unknown function (DUF4688)
    pfam17069
    Location:197380
    RSRP; Arginine/Serine-Rich protein 1
    cl17036
    Location:735791
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:12501324
    PH-like; Pleckstrin homology-like domain
  6. NM_001270229.4NP_001257158.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257158.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3YT13
    Conserved Domains (6) summary
    smart00139
    Location:8981053
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:10601273
    B41; Band 4.1 homologues
    pfam00373
    Location:11511273
    FERM_M; FERM central domain
    pfam17069
    Location:197380
    RSRP; Arginine/Serine-Rich protein 1
    cl17036
    Location:772828
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:12871361
    PH-like; Pleckstrin homology-like domain
  7. NM_001307863.4NP_001294792.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294792.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6EZR2
    Conserved Domains (7) summary
    smart00139
    Location:772927
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:9341147
    B41; Band 4.1 homologues
    pfam00373
    Location:10251147
    FERM_M; FERM central domain
    pfam15512
    Location:237341
    CAF-1_p60_C; Chromatin assembly factor complex 1 subunit p60, C-terminal
    pfam17069
    Location:108291
    RSRP; Arginine/Serine-Rich protein 1
    cl17036
    Location:646702
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:11611235
    PH-like; Pleckstrin homology-like domain
  8. NM_001270230.4NP_001257159.1  Myosin motor domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001257159.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D3YT14
    Conserved Domains (6) summary
    smart00139
    Location:809964
    MyTH4; Domain in Myosin and Kinesin Tails
    smart00295
    Location:9711184
    B41; Band 4.1 homologues
    pfam00373
    Location:10621184
    FERM_M; FERM central domain
    pfam17069
    Location:108291
    RSRP; Arginine/Serine-Rich protein 1
    cl17036
    Location:683739
    SH3; Src Homology 3 domain superfamily
    cl17171
    Location:11981272
    PH-like; Pleckstrin homology-like domain