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noca-2 EF-hand domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181354, updated on 2-Nov-2024

Summary

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Official Symbol
noca-2
Official Full Name
EF-hand domain-containing protein
Primary source
WormBase:WBGene00011444
Locus tag
CELE_T04F8.6
See related
AllianceGenome:WB:WBGene00011444
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in microtubule anchoring at centrosome. Predicted to be active in centrosome. Is expressed in PVDL; PVDR; head; seam cell; and tail. Human ortholog(s) of this gene implicated in Seckel syndrome 7. Orthologous to human NIN (ninein) and NINL (ninein like). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See noca-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
19
Sequence:
Chromosome: X; NC_003284.9 (11667127..11672309)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Sidoreflexin Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. PTRN-1 (CAMSAP) and NOCA-2 (NINEIN) are required for microtubule polarity in Caenorhabditis elegans dendrites. He L, et al. PLoS Biol, 2022 Nov. PMID 36395330, Free PMC Article
  2. An actin-based viscoplastic lock ensures progressive body-axis elongation. Lardennois A, et al. Nature, 2019 Sep. PMID 31462781, Free PMC Article
  3. The relationship between intraflagellar transport and upstream protein trafficking pathways and macrocyclic lactone resistance in Caenorhabditis elegans. Brinzer RA, et al. G3 (Bethesda), 2024 Mar 6. PMID 38227795, Free PMC Article
  4. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in microtubule anchoring at centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
EF-hand domain-containing protein
NP_509950.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11667127..11672309
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077549.4 → NP_509950.3  EF-hand domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_509950.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22167
    Conserved Domains (1) summary
    TIGR02169
    Location:258 → 437
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
Nucleotide Protein
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