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sma-5 Mitogen-activated protein kinase sma-5;Protein kinase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181373, updated on 2-Nov-2024

Summary

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Official Symbol
sma-5
Official Full Name
Mitogen-activated protein kinase sma-5;Protein kinase domain-containing protein
Primary source
WormBase:WBGene00004859
Locus tag
CELE_W06B3.2
See related
AllianceGenome:WB:WBGene00004859
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in several processes, including determination of adult lifespan; parturition; and positive regulation of cell size. Predicted to be active in cytoplasm and nucleus. Is expressed in excretory cell; hypodermis; intestine; and pharynx. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sma-5 in Genome Data Viewer
Location:
chromosome: X
Exon count:
10
Sequence:
Chromosome: X; NC_003284.9 (11997524..12005004, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene tRNA-His Neighboring gene Acyl carrier protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Control of body size by SMA-5, a homolog of MAP kinase BMK1/ERK5, in C. elegans. Watanabe N, et al. Development, 2005 Jul. PMID 15944183
  2. A novel function for the MAP kinase SMA-5 in intestinal tube stability. Geisler F, et al. Mol Biol Cell, 2016 Dec 1. PMID 27733627, Free PMC Article
  3. BBLN-1 is essential for intermediate filament organization and apical membrane morphology. Remmelzwaal S, et al. Curr Biol, 2021 Jun 7. PMID 33857431
  4. Mutants carrying two sma mutations are super small in the nematode C. elegans. Watanabe N, et al. Genes Cells, 2007 May. PMID 17535251
  5. lon-1 regulates Caenorhabditis elegans body size downstream of the dbl-1 TGF beta signaling pathway. Maduzia LL, et al. Dev Biol, 2002 Jun 15. PMID 12051826

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in organelle localization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in parturition IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in parturition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cell growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell size IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of multicellular organism growth IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-embryonic development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Mitogen-activated protein kinase sma-5;Protein kinase domain-containing protein
NP_001041297.1
  • Confirmed by transcript evidence
NP_001366649.1
  • Confirmed by transcript evidence
NP_001379447.1
  • Confirmed by transcript evidence
NP_001391190.1
  • Confirmed by transcript evidence
NP_001407511.1
  • Confirmed by transcript evidence
NP_741908.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    11997524..12005004 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392855.1 → NP_001379447.1  Mitogen-activated protein kinase sma-5 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd07855
    Location:30 → 374
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  2. NM_171782.6 → NP_741908.1  Mitogen-activated protein kinase sma-5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741908.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EBT1
    Conserved Domains (2) summary
    smart00220
    Location:82 → 388
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07855
    Location:79 → 423
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  3. NM_001420578.1 → NP_001407511.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QDG2

  4. NM_001381114.3 → NP_001366649.1  Mitogen-activated protein kinase sma-5 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd07855
    Location:79 → 423
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  5. NM_001047832.3 → NP_001041297.1  Mitogen-activated protein kinase sma-5 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041297.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EBE9, G5EBM8, G5EBT1, G5EDH5
    Conserved Domains (2) summary
    smart00220
    Location:105 → 411
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd07855
    Location:102 → 446
    STKc_ERK5; Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5

  6. NM_001404211.1 → NP_001391190.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A8S4QBG0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EBT1.1

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