F17E5.2 putative calcium-binding mitochondrial carrier F17E5.2 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: F17E5.2
Official Full Name: putative calcium-binding mitochondrial carrier F17E5.2
Primary source: WormBase:WBGene00008924
Locus tag: CELE_F17E5.2
See related: AllianceGenome:WB:WBGene00008924
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP transmembrane transporter activity. Predicted to be involved in ADP transport and ATP transport. Predicted to be located in mitochondrial inner membrane. Orthologous to several human genes including SLC25A25 (solute carrier family 25 member 25). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See F17E5.2 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 13

Sequence:: Chromosome: X; NC_003284.9 (12394265..12399534)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F17E5.2 (e-PCR)
- UniSTS:309803

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ADP transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in ATP transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative calcium-binding mitochondrial carrier F17E5.2

NP_510081.3

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

12394265..12399534

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077680.9 → NP_510081.3 putative calcium-binding mitochondrial carrier F17E5.2 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510081.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q19529

Conserved Domains (5) summary

COG5126
Location:67 → 206

FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]

cd00051
Location:140 → 201

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...

PTZ00169
Location:249 → 526

PTZ00169; ADP/ATP transporter on adenylate translocase; Provisional

pfam00153
Location:337 → 429

Mito_carr; Mitochondrial carrier protein

cl08302
Location:74 → 160

EFh; EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to ...