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ivns-1 BTB domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181410, updated on 2-Nov-2024

Summary

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Official Symbol
ivns-1
Official Full Name
BTB domain-containing protein
Primary source
WormBase:WBGene00006493
Locus tag
CELE_R09A8.3
See related
AllianceGenome:WB:WBGene00006493
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in immunodeficiency 70. Orthologous to human IVNS1ABP (influenza virus NS1A binding protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ivns-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
11
Sequence:
Chromosome: X; NC_003284.9 (12624655..12629110, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Protein kinase domain-containing protein;TPX2 domain-containing protein Neighboring gene Dentin sialophosphoprotein-like Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expanded genetic screening in Caenorhabditis elegans identifies new regulators and an inhibitory role for NAD(+) in axon regeneration. Kim KW, et al. Elife, 2018 Nov 21. PMID 30461420, Free PMC Article
  2. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article
  3. In Vivo Interaction Proteomics in Caenorhabditis elegans Embryos Provides New Insights into P Granule Dynamics. Chen JX, et al. Mol Cell Proteomics, 2016 May. PMID 26912668, Free PMC Article
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ubiquitin-like ligase-substrate adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of Cul3-RING ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
BTB domain-containing protein
NP_510109.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    12624655..12629110 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077708.9 → NP_510109.1  BTB domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510109.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21854
    Conserved Domains (4) summary
    PHA03098
    Location:183 → 735
    PHA03098; kelch-like protein; Provisional
    sd00038
    Location:505 → 548
    Kelch; KELCH repeat [structural motif]
    cl38908
    Location:77 → 241
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
    pfam01344
    Location:744 → 774
    Kelch_1; Kelch motif
Nucleotide Protein
Heading Accession and Version

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