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pgp-12 P-GlycoProtein related [ Caenorhabditis elegans ]

Gene ID: 181415, updated on 9-Dec-2024

Summary

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Official Symbol
pgp-12
Official Full Name
P-GlycoProtein related
Primary source
WormBase:WBGene00004006
Locus tag
CELE_F22E10.1
See related
AllianceGenome:WB:WBGene00004006
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATPase-coupled transmembrane transporter activity. Involved in response to nematicide. Predicted to be active in membrane. Is expressed in several structures, including excretory cell; hypodermis; intestine; pharynx; and tail. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); cholestasis (multiple); drug dependence (multiple); and human immunodeficiency virus infectious disease (multiple). Orthologous to several human genes including ABCB1 (ATP binding cassette subfamily B member 1); ABCB11 (ATP binding cassette subfamily B member 11); and ABCB4 (ATP binding cassette subfamily B member 4). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See pgp-12 in Genome Data Viewer
Location:
chromosome: X
Exon count:
15
Sequence:
Chromosome: X; NC_003284.9 (12731807..12737441)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Nuclear hormone receptor family member nhr-27 Neighboring gene RGS domain-containing protein;Regulator of G-protein signaling rgs-2 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene P-GlycoProtein related Neighboring gene P-glycoprotein 14

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Dominance of P-glycoprotein 12 in phenotypic resistance conversion against ivermectin in Caenorhabditis elegans. Figueiredo LA, et al. PLoS One, 2018. PMID 29474375, Free PMC Article
  2. Inhibition of P-glycoprotein enhances sensitivity of Caenorhabditis elegans to ivermectin. Ardelli BF, et al. Vet Parasitol, 2013 Jan 31. PMID 23062691
  3. Distinct regulatory elements mediate similar expression patterns in the excretory cell of Caenorhabditis elegans. Zhao Z, et al. J Biol Chem, 2005 Nov 18. PMID 16159881
  4. Resistance to the macrocyclic lactone moxidectin is mediated in part by membrane transporter P-glycoproteins: Implications for control of drug resistant parasitic nematodes. Bygarski EE, et al. Int J Parasitol Drugs Drug Resist, 2014 Dec. PMID 25516824, Free PMC Article
  5. The role of several ABC transporter genes in ivermectin resistance in Caenorhabditis elegans. Yan R, et al. Vet Parasitol, 2012 Dec 21. PMID 22840641

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ABC-type transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATPase-coupled transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in response to chemical IEA
Inferred from Electronic Annotation
more info
  
involved_in response to nematicide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
P-GlycoProtein related
NP_510126.1
  • Product from WormBase gene class pgp;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    12731807..12737441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077725.6 → NP_510126.1  P-GlycoProtein related [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510126.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19733
    Conserved Domains (4) summary
    cd03249
    Location:417 → 654
    ABC_MTABC3_MDL1_MDL2; ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins
    PTZ00265
    Location:145 → 1312
    PTZ00265; multidrug resistance protein (mdr1); Provisional
    pfam00664
    Location:97 → 332
    ABC_membrane; ABC transporter transmembrane region
    cl00549
    Location:762 → 1005
    ABC_membrane; ABC transporter transmembrane region
Nucleotide Protein
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