alh-13 Glutamate 5-kinase [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: alh-13
Official Full Name: Glutamate 5-kinase
Primary source: WormBase:WBGene00011938
Locus tag: CELE_T22H6.2
See related: AllianceGenome:WB:WBGene00011938
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable glutamate-5-semialdehyde dehydrogenase activity. Predicted to be involved in L-proline biosynthetic process. Located in mitochondrion. Is expressed in intestine. Human ortholog(s) of this gene implicated in cataract; cutis laxa (multiple); enterocele; and hereditary spastic paraplegia (multiple). Orthologous to human ALDH18A1 (aldehyde dehydrogenase 18 family member A1). [provided by Alliance of Genome Resources, Dec 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See alh-13 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 9

Sequence:: Chromosome: X; NC_003284.9 (12782394..12787147)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

T22H6.2 (e-PCR)
- UniSTS:310963

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables catalytic activity	IEA Inferred from Electronic Annotation more info
enables glutamate 5-kinase activity	IEA Inferred from Electronic Annotation more info
enables glutamate-5-semialdehyde dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables glutamate-5-semialdehyde dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-proline biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in amino acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in proline biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

Go to the top of the page Help

Preferred Names: Glutamate 5-kinase

NP_510132.2

Confirmed by transcript evidence

NP_510133.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

12782394..12787147

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_077731.7 → NP_510132.2 Glutamate 5-kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510132.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P54889, Q9BI69

Conserved Domains (3) summary

TIGR01092
Location:75 → 782

P5CS; delta l-pyrroline-5-carboxylate synthetase

cd07079
Location:357 → 763

ALDH_F18-19_ProA-GPR; Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19

cd04256
Location:74 → 346

AAK_P5CS_ProBA; AAK_P5CS_ProBA: Glutamate-5-kinase (G5K) domain of the bifunctional delta 1-pyrroline-5-carboxylate synthetase (P5CS), composed of an N-terminal G5K (ProB) and a C-terminal glutamyl 5- phosphate reductase (G5PR, ProA), the first and second enzyme ...
NM_077732.9 → NP_510133.2 Glutamate 5-kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510133.2

Status: REVIEWED

UniProtKB/Swiss-Prot

P54889

Conserved Domains (3) summary

TIGR01092
Location:73 → 780

P5CS; delta l-pyrroline-5-carboxylate synthetase

cd07079
Location:355 → 761

ALDH_F18-19_ProA-GPR; Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19

cd04256
Location:72 → 344

AAK_P5CS_ProBA; AAK_P5CS_ProBA: Glutamate-5-kinase (G5K) domain of the bifunctional delta 1-pyrroline-5-carboxylate synthetase (P5CS), composed of an N-terminal G5K (ProB) and a C-terminal glutamyl 5- phosphate reductase (G5PR, ProA), the first and second enzyme ...