T14G8.3 Hypoxia up-regulated protein 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: T14G8.3
Official Full Name: Hypoxia up-regulated protein 1
Primary source: WormBase:WBGene00011771
Locus tag: CELE_T14G8.3
See related: AllianceGenome:WB:WBGene00011771
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable adenyl-nucleotide exchange factor activity. Involved in IRE1-mediated unfolded protein response. Predicted to be part of endoplasmic reticulum chaperone complex. Human ortholog(s) of this gene implicated in immunodeficiency 59. Orthologous to human HYOU1 (hypoxia up-regulated 1). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See T14G8.3 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 14

Sequence:: Chromosome: X; NC_003284.9 (12861237..12870025)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T14G8.3 (e-PCR)
- UniSTS:310851

T14G8.4 (e-PCR)
- UniSTS:308037

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables adenyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in IRE1-mediated unfolded protein response	HEP more info	PubMed
involved_in endoplasmic reticulum unfolded protein response	HEP more info	PubMed
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in response to stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of endoplasmic reticulum chaperone complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Hypoxia up-regulated protein 1

NP_001024913.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

12861237..12870025

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029742.7 → NP_001024913.1 Hypoxia up-regulated protein 1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024913.1

Status: REVIEWED

UniProtKB/TrEMBL

Q22515

Conserved Domains (1) summary

cd10230
Location:29 → 416

HYOU1-like_NBD; Nucleotide-binding domain of human HYOU1 and similar proteins