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jmjd-3.3 JmjC domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181467, updated on 4-Jan-2025

Summary

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Official Symbol
jmjd-3.3
Official Full Name
JmjC domain-containing protein
Primary source
WormBase:WBGene00007813
Locus tag
CELE_C29F7.6
See related
AllianceGenome:WB:WBGene00007813
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin DNA binding activity; and histone H3K27me2/H3K27me3 demethylase activity. Predicted to be involved in regulation of gene expression. Predicted to be located in nucleus. Predicted to be part of MLL3/4 complex. [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See jmjd-3.3 in Genome Data Viewer
Location:
chromosome: X
Exon count:
7
Sequence:
Chromosome: X; NC_003284.9 (13436422..13441438)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene tRNA-Ile Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene tRNA-Leu

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. UTX and JMJD3 are histone H3K27 demethylases involved in HOX gene regulation and development. Agger K, et al. Nature, 2007 Oct 11. PMID 17713478
  2. Histone demethylase UTX-1 regulates C. elegans life span by targeting the insulin/IGF-1 signaling pathway. Jin C, et al. Cell Metab, 2011 Aug 3. PMID 21803287
  3. Epigenetics in C. elegans: facts and challenges. Wenzel D, et al. Genesis, 2011 Aug. PMID 21538806
  4. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone H3K27me2/H3K27me3 demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of MLL3/4 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
JmjC domain-containing protein
NP_001309680.1
  • Confirmed by transcript evidence
NP_001309681.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    13436422..13441438
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001322643.5 → NP_001309680.1  JmjC domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MD13
    Conserved Domains (1) summary
    pfam02373
    Location:497 → 604
    JmjC; JmjC domain, hydroxylase

  2. NM_001322644.3 → NP_001309681.1  JmjC domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A131MD67
    Conserved Domains (1) summary
    pfam02373
    Location:73 → 180
    JmjC; JmjC domain, hydroxylase
Nucleotide Protein
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