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meg-1 Protein meg-1 [ Caenorhabditis elegans ]

Gene ID: 181502, updated on 2-Nov-2024

Summary

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Official Symbol
meg-1
Official Full Name
Protein meg-1
Primary source
WormBase:WBGene00010492
Locus tag
CELE_K02B9.1
See related
AllianceGenome:WB:WBGene00010492
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in P granule disassembly and germ cell proliferation. Located in P granule. Is expressed in germ line; germline blastomere; and oocyte. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See meg-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (13927036..13929634, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Protein meg-2 Neighboring gene pseudo Neighboring gene Transcription factor elt-3 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Specialized germline P-bodies are required to specify germ cell fate in Caenorhabditis elegans embryos. Cassani M, et al. Development, 2022 Nov 1. PMID 36196602, Free PMC Article
  2. Caenorhabditis elegans DLC-1 associates with ribonucleoprotein complexes to promote mRNA regulation. Day NJ, et al. FEBS Lett, 2018 Nov. PMID 30264890, Free PMC Article
  3. C. elegans meg-1 and meg-2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival. Kapelle WS, et al. Genesis, 2011 May. PMID 21305687
  4. MEG-1 and MEG-2 are embryo-specific P-granule components required for germline development in Caenorhabditis elegans. Leacock SW, et al. Genetics, 2008 Jan. PMID 18202375, Free PMC Article
  5. Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans. Wang JT, et al. Elife, 2014 Dec 23. PMID 25535836, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that meg-1 and meg-2 differentially interact with the nanos family nos-1, nos-2 and nos-3 for germ cell proliferaiton.
    Title: C. elegans meg-1 and meg-2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in P granule disassembly IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in germ cell proliferation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in multicellular organismal reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Protein meg-1
NP_510319.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    13927036..13929634 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_077918.8 → NP_510319.1  Protein meg-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510319.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21126
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21126.2

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