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slt-1 Slit homolog 1 protein [ Caenorhabditis elegans ]

Gene ID: 181562, updated on 4-Jan-2025

Summary

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Official Symbol
slt-1
Official Full Name
Slit homolog 1 protein
Primary source
WormBase:WBGene00004854
Locus tag
CELE_F40E10.4
See related
AllianceGenome:WB:WBGene00004854
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables signaling receptor binding activity. Involved in axon guidance; neuron migration; and regulation of neuron projection development. Predicted to be located in extracellular region. Is expressed in anal sphincter muscle; anterior hypodermis; body wall musculature; nerve ring neurons; and socket cell. Orthologous to human SLIT1 (slit guidance ligand 1); SLIT2 (slit guidance ligand 2); and SLIT3 (slit guidance ligand 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See slt-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
32
Sequence:
Chromosome: X; NC_003284.9 (14674328..14683324)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Hyphal_reg_CWP domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Ile Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Calsequestrin

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ANC-1 (Nesprin-1/2) organelle-anchoring protein functions through mitochondria to polarize axon growth in response to SLT-1. Fischer NC, et al. PLoS Genet, 2022 Nov. PMID 36409768, Free PMC Article
  2. mau-2 acts cell-autonomously to guide axonal migrations in Caenorhabditis elegans. Bénard CY, et al. Development, 2004 Dec. PMID 15539489
  3. The Caenorhabditis elegans NF2/Merlin Molecule NFM-1 Nonautonomously Regulates Neuroblast Migration and Interacts Genetically with the Guidance Cue SLT-1/Slit. Josephson MP, et al. Genetics, 2017 Feb. PMID 27913619, Free PMC Article
  4. The C. elegans CDK8 Mediator module regulates axon guidance decisions in the ventral nerve cord and during dorsal axon navigation. Steimel A, et al. Dev Biol, 2013 May 15. PMID 23458898
  5. UNC-6/netrin and SLT-1/slit guidance cues orient axon outgrowth mediated by MIG-10/RIAM/lamellipodin. Quinn CC, et al. Curr Biol, 2006 May 9. PMID 16563765

See all (58) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. these observations suggest that MIG-10 interacts with ABI-1 and WVE-1 to mediate the UNC-6 and SLT-1 guidance pathways.
    Title: MIG-10 functions with ABI-1 to mediate the UNC-6 and SLT-1 axon guidance signaling pathways.
  2. EVA-1 identified as a transmembrane receptor for SLT-1; EVA-1 acts cell-autonomously for SLT-1/Slit-dependent axon migration functions of SAX-3/Robo, colocalizes with SAX-3 on cells & provides cell specificity to activation of SAX-3 signaling by SLT-1
    Title: The slit receptor EVA-1 coactivates a SAX-3/Robo mediated guidance signal in C. elegans.
  3. Genetic analyses indicate that MIG-10/RIAM/lamellipodin, a cytoplasmic adaptor protein, functions downstream of the repulsive guidance cue SLT-1/slit to direct the ventral migration of the AVM and PVM axons in C. elegans.
    Title: UNC-6/netrin and SLT-1/slit guidance cues orient axon outgrowth mediated by MIG-10/RIAM/lamellipodin.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables Roundabout binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables heparin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in axon midline choice point recognition IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cellular component organization IEA
Inferred from Electronic Annotation
more info
  
involved_in dorsal/ventral axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dorsal/ventral axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of axon extension involved in axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of sensory neuron axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sensory neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Slit homolog 1 protein
NP_510437.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    14674328..14683324
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078036.8 → NP_510437.2  Slit homolog 1 protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510437.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFX6
    Conserved Domains (9) summary
    smart00013
    Location:259 → 291
    LRRNT; Leucine rich repeat N-terminal domain
    smart00041
    Location:1334 → 1405
    CT; C-terminal cystine knot-like domain (CTCK)
    smart00082
    Location:195 → 243
    LRRCT; Leucine rich repeat C-terminal domain
    smart00282
    Location:1133 → 1268
    LamG; Laminin G domain
    cd00054
    Location:947 → 983
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00116
    Location:514 → 635
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:48 → 69
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:311 → 352
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:729 → 788
    LRR_8; Leucine rich repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EFX6.1

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