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epn-1 ENTH domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181577, updated on 4-Jan-2025

Summary

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Official Symbol
epn-1
Official Full Name
ENTH domain-containing protein
Primary source
WormBase:WBGene00001329
Locus tag
CELE_T04C10.2
See related
AllianceGenome:WB:WBGene00001329
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable clathrin binding activity and phospholipid binding activity. Predicted to be involved in endocytosis. Located in early phagosome; phagocytic cup; and pseudopodium. Is expressed in several structures, including coelomocyte; hypodermis; intestine; nervous system; and reproductive system. Orthologous to human EPN1 (epsin 1); EPN2 (epsin 2); and EPN3 (epsin 3). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

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See epn-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
6
Sequence:
Chromosome: X; NC_003284.9 (14815798..14818514, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene Transcription factor atf-4 homolog Neighboring gene ncRNA Neighboring gene Coiled-coil domain-containing protein 96 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A C. elegans genome-wide RNAi screen for altered levamisole sensitivity identifies genes required for muscle function. Chaya T, et al. G3 (Bethesda), 2021 Apr 15. PMID 33713125, Free PMC Article
  2. Phagocytic receptor signaling regulates clathrin and epsin-mediated cytoskeletal remodeling during apoptotic cell engulfment in C. elegans. Shen Q, et al. Development, 2013 Aug. PMID 23861060, Free PMC Article
  3. Evolutionary plasticity in the requirement for force exerted by ligand endocytosis to activate C. elegans Notch proteins. Langridge PD, et al. Curr Biol, 2022 May 23. PMID 35349791, Free PMC Article
  4. Caenorhabditis elegans reveals a FxNPxY-independent low-density lipoprotein receptor internalization mechanism mediated by epsin1. Kang YL, et al. Mol Biol Cell, 2013 Feb. PMID 23242996, Free PMC Article
  5. Co-regulation by Notch and Fos is required for cell fate specification of intermediate precursors during C. elegans uterine development. Oommen KS, et al. Development, 2007 Nov. PMID 17942488

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Inactivating epn-1 or chc-1 disrupts engulfment by impairing actin polymerization. CHC-1 is enriched on extending pseudopods together with EPN-1, in an EPN-1-dependent manner.
    Title: Phagocytic receptor signaling regulates clathrin and epsin-mediated cytoskeletal remodeling during apoptotic cell engulfment in C. elegans.
  2. EPN-1/epsin as an essential factor in promoting internalization of the C. elegans LDLR superfamily member LRP-1.
    Title: Caenorhabditis elegans reveals a FxNPxY-independent low-density lipoprotein receptor internalization mechanism mediated by epsin1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of clathrin vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early phagosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in phagocytic cup IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pseudopodium IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ENTH domain-containing protein
NP_510458.1
  • Confirmed by transcript evidence
NP_510459.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    14815798..14818514 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078058.6 → NP_510459.1  ENTH domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510459.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BI72
    Conserved Domains (1) summary
    cd16990
    Location:19 → 141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family

  2. NM_078057.8 → NP_510458.1  ENTH domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510458.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9BI71
    Conserved Domains (1) summary
    cd16990
    Location:19 → 141
    ENTH_Epsin; Epsin N-Terminal Homology (ENTH) domain of Epsin family
Nucleotide Protein
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