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mbk-1 Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1 [ Caenorhabditis elegans ]

Gene ID: 181578, updated on 9-Dec-2024

Summary

Official Symbol
mbk-1
Official Full Name
Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1
Primary source
WormBase:WBGene00003149
Locus tag
CELE_T04C10.1
See related
AllianceGenome:WB:WBGene00003149
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA-templated transcription. Predicted to be active in nucleus. Is expressed in several structures, including anterior gonad arm. Used to study Down syndrome and intellectual disability. Human ortholog(s) of this gene implicated in Down syndrome; abdominal obesity-metabolic syndrome 3; autism spectrum disorder; autosomal dominant intellectual developmental disorder 7; and intellectual disability. Orthologous to several human genes including DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

See mbk-1 in Genome Data Viewer
Location:
chromosome: X
Exon count:
11
Sequence:
Chromosome: X; NC_003284.9 (14819909..14824540, complement)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine/tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in positive regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in response to stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1
NP_510460.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    14819909..14824540 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078059.7NP_510460.2  Dual specificity tyrosine-phosphorylation-regulated kinase mbk-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510460.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22155, Q8WQL7
    Conserved Domains (2) summary
    smart00220
    Location:326649
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14226
    Location:312651
    PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1