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ucr-2.2 Peptidase M16 N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181611, updated on 2-Nov-2024

Summary

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Official Symbol
ucr-2.2
Official Full Name
Peptidase M16 N-terminal domain-containing protein
Primary source
WormBase:WBGene00011679
Locus tag
CELE_T10B10.2
See related
AllianceGenome:WB:WBGene00011679
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloendopeptidase activity. Predicted to be involved in protein processing. Predicted to be active in mitochondrial matrix. Is expressed in several structures, including excretory cell; intestine; nervous system; pharynx; and vulval muscle. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency nuclear type 5. Orthologous to human UQCRC2 (ubiquinol-cytochrome c reductase core protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ucr-2.2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (15173904..15178145)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Nucleotide-diphospho-sugar transferase Neighboring gene Secreted protein Neighboring gene Ion transport domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene PH domain-containing protein;RUN domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification and reverse genetic analysis of mitochondrial processing peptidase and the core protein of the cytochrome bc1 complex of Caenorhabditis elegans, a model parasitic nematode. Nomura H, et al. J Biochem, 2006 Jun. PMID 16788047
  2. Mitochondrial modulation of phosphine toxicity and resistance in Caenorhabditis elegans. Zuryn S, et al. Toxicol Sci, 2008 Mar. PMID 17998274
  3. SAFER, an Analysis Method of Quantitative Proteomic Data, Reveals New Interactors of the C. elegans Autophagic Protein LGG-1. Yi Z, et al. J Proteome Res, 2016 May 6. PMID 26999449
  4. FACT Sets a Barrier for Cell Fate Reprogramming in Caenorhabditis elegans and Human Cells. Kolundzic E, et al. Dev Cell, 2018 Sep 10. PMID 30078731, Free PMC Article
  5. Caenorhabditis elegans ALG-1 antimorphic mutations uncover functions for Argonaute in microRNA guide strand selection and passenger strand disposal. Zinovyeva AY, et al. Proc Natl Acad Sci U S A, 2015 Sep 22. PMID 26351692, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial matrix IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Peptidase M16 N-terminal domain-containing protein
NP_510521.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    15173904..15178145
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078120.5 → NP_510521.1  Peptidase M16 N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510521.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22370
    Conserved Domains (3) summary
    COG0612
    Location:23 → 401
    PqqL; Predicted Zn-dependent peptidase [General function prediction only]
    pfam00675
    Location:37 → 176
    Peptidase_M16; Insulinase (Peptidase family M16)
    pfam05193
    Location:188 → 352
    Peptidase_M16_C; Peptidase M16 inactive domain
Nucleotide Protein
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