piki-1 Phosphatidylinositol 3-kinase piki-1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: piki-1
Official Full Name: Phosphatidylinositol 3-kinase piki-1
Primary source: WormBase:WBGene00009552
Locus tag: CELE_F39B1.1
See related: AllianceGenome:WB:WBGene00009552
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 1-phosphatidylinositol-3-kinase activity and 1-phosphatidylinositol-4-phosphate 3-kinase activity. Involved in several processes, including phagosome maturation involved in apoptotic cell clearance; phosphatidylinositol-3-phosphate biosynthetic process; and positive regulation of phagocytosis, engulfment. Located in early phagosome and pseudopodium. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to several human genes including PIK3C2A (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha) and PIK3C2B (phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See piki-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 23

Sequence:: Chromosome: X; NC_003284.9 (15234690..15246399, complement)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Autophagy may coordinate with PIKI-1 to promote phagosome maturation, thus ensuring efficient clearance of apoptotic cells.
Title: Autophagy genes coordinate with the class II PI/PtdIns 3-kinase PIKI-1 to regulate apoptotic cell clearance in C. elegans.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F39B1.1 (e-PCR)
- UniSTS:321456

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-3-kinase activity	IEA Inferred from Electronic Annotation more info
enables 1-phosphatidylinositol-3-kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables 1-phosphatidylinositol-4-phosphate 3-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phagocytosis	IEA Inferred from Electronic Annotation more info
involved_in phagosome maturation involved in apoptotic cell clearance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in phagosome maturation involved in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol-3-phosphate biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phagocytosis, engulfment	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of phagocytosis, engulfment	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in early phagosome	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in phagocytic cup	IEA Inferred from Electronic Annotation more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in pseudopodium	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Phosphatidylinositol 3-kinase piki-1

NP_510529.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

15234690..15246399 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078128.6 → NP_510529.1 Phosphatidylinositol 3-kinase piki-1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510529.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EDY0

Conserved Domains (6) summary

cd04012
Location:593 → 775

C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

cd08381
Location:1473 → 1604

C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)

smart00144
Location:348 → 456

PI3K_rbd; PI3-kinase family, Ras-binding domain

cd00869
Location:784 → 948

PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...

cd05166
Location:964 → 1315

PI3Kc_II; Catalytic domain of Class II Phosphoinositide 3-kinase

cl02563
Location:1346 → 1454

PX_domain; The Phox Homology domain, a phosphoinositide binding module