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cpd-2 Peptidase M14 carboxypeptidase A domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 181684, updated on 2-Nov-2024

Summary

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Official Symbol
cpd-2
Official Full Name
Peptidase M14 carboxypeptidase A domain-containing protein
Primary source
WormBase:WBGene00012073
Locus tag
CELE_T27A8.1
See related
AllianceGenome:WB:WBGene00012073
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metallocarboxypeptidase activity. Involved in regulation of muscle contraction. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in alcohol dependence; carboxypeptidase N deficiency; coronary artery disease; obesity; and type 2 diabetes mellitus. Orthologous to human CPE (carboxypeptidase E); CPM (carboxypeptidase M); and CPN1 (carboxypeptidase N subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cpd-2 in Genome Data Viewer
Location:
chromosome: X
Exon count:
8
Sequence:
Chromosome: X; NC_003284.9 (16049873..16054646)

Chromosome X - NC_003284.9Genomic Context describing neighboring genes Neighboring gene Choline/carnitine acyltransferase domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Ser Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Multiple checkpoints of protein clearance machinery are modulated by a common microRNA, miR-4813-3p, through its putative target genes: Studies employing transgenic C. elegans model. Sarkar A, et al. Biochim Biophys Acta Mol Cell Res, 2022 Dec. PMID 35998789
  2. Neuropeptides function in a homeostatic manner to modulate excitation-inhibition imbalance in C. elegans. Stawicki TM, et al. PLoS Genet, 2013 May. PMID 23658528, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metallocarboxypeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallocarboxypeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in peptide metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of muscle contraction IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Peptidase M14 carboxypeptidase A domain-containing protein
NP_510625.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003284.9 Reference assembly

    Range
    16049873..16054646
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078224.8 → NP_510625.2  Peptidase M14 carboxypeptidase A domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_510625.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22825
    Conserved Domains (2) summary
    cd11308
    Location:358 → 433
    Peptidase_M14NE-CP-C_like; Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain
    cd03858
    Location:58 → 352
    M14_CP_N-E_like; Peptidase M14 carboxypeptidase subfamily N/E-like
Nucleotide Protein
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